Results 251 to 260 of about 192,388 (308)

Spatial omics and AI for clinically actionable cancer biomarkers. [PDF]

PLoS Med
Reitsam NG.
europepmc   +1 more source

Alzheimer’s Tau seeds-induced pathology enhances hippocampal extracellular diffusion

Communications Biology
Juan Estaún-Panzano, Anna Lovisotto, Claire Mazzocco, Carolina Piva, Morgane Darricau, Ivo Calaresu, Quentin Gresil, Vincent Planche, Benjamin Dehay, Laurent Groc, Laurent Cognet, Erwan Bezard   +11 more
openaire   +1 more source

Integrated Single‐Cell and Spatial Transcriptomics Reveal Cell‐Type‐Specific Immune Regulatory Networks in Maize Responding to Southern Corn Rust

Advanced Science, EarlyView.
By integrating single‐nuclei and spatial transcriptomics, this study presents a stereoscopic landscape of maize leaf to Puccinia polysora infection. Epidermal and mesophyll cells initiate primary defenses via RLPs/RLKs and jasmonic acid signaling. Cell‐cell communication analyses further reveal the underlying the dynamics of the underlying immune ...
Qiongqiong Wang, Xinyan Sun, Yingchao Sun, Zeqiang Cheng, Zixiang Cheng, Shengbo Han, Ying Feng, Wenbo Yang, Huimin Li, Meichen Zhu, Xiaoling Wu, Jinghua Zhang, Jihua Tang, Honglian Li, Yanyong Cao, Canxing Duan, Yan Shi   +16 more
wiley   +1 more source

Beyond prion-like spreading in neurodegenerative disease. [PDF]

Alzheimers Dement
Meisl G, Rowe JB, Klenerman D.
europepmc   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

CFG-MambaNet: Contextual and Frequency-Guided Mamba Network for medical image segmentation. [PDF]

NPJ Digit Med
Ren G, Chen Z, Su P, Li D, Yang X, Gai D, Wei X, Xu W, Chen H, Zhao X, Wang X, Liu P, Ye H, Ma Y.   +13 more
europepmc   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Detection of TDP-43 seeds in CSF of presymptomatic and symptomatic genetic FTD/ALS. [PDF]

Alzheimers Dement
Dellarole IL, Aprea V, Catania M, Battipaglia C, Romeo A, Villa C, Burato A, Celauro L, Bella ED, Riva N, Salvi E, Rossi G, Fede GD, Legname G, De Houwer JFH, Alberici A, Borroni B, Seelaar H, van Swieten JC, Moda F, Caroppo P.   +20 more
europepmc   +1 more source