Results 121 to 130 of about 7,737,227 (359)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Овощи России, 2009 Timiryazevka is a familiar and a widely used name of Timiryazev Academy of Agriculture among students, professors and remains a homely place for all university mates ever graduated the academy.
H.G. Dobrutskaya +2 more
doaj +1 more source
Incentive to reduce crop trait durability [PDF]
Inbred line seed producers face competition from their own consumers: farmers who save part of their harvest can costly self-produce. To reduce this competition, seed producers can switch to non-durable hybrid seed production.
Ambec, Stefan +2 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Transcriptome analysis of the model grass Lolium temulentum exposed to green leaf volatiles
BMC Plant Biology, 2019 Background Forage and turf grasses are routinely cut and grazed upon throughout their lifecycle. When grasses are cut or damaged, they rapidly release a volatile chemical cocktail called green leaf volatiles (GLV).
James E. Dombrowski +5 more
doaj +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Activation of MAP kinases by green leaf volatiles in grasses
BMC Research Notes, 2018 Objective Previously we have shown that mechanical wounding and volatiles released from cut grass, activated a 46 and 44 kDa mitogen-activated protein kinase (MAPK) in the model grass species Lolium temulentum (Lt). MAPKs play an important role as signal
James E. Dombrowski, Ruth C. Martin
doaj +1 more source
Cumulative individual seed production in the polycarpic Caesalpinia gilliesii (Fabaceae): effects of temporal variability in floral display, plant density and pollination [PDF]
, 2016 In polycarpic species, floral display size and density of conspecific neighbours are time variable as well as their effects on pollination and fecundity.
Ashworth, Lorena +2 more
core
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Proceedings of the New Zealand Grassland Association, 1962 Lucerne is grown for seed chiefly in Marlborough and North Canterbury with a small amount in Mid Canterbury. The variation in the areas harvested from year to year indicates two important factors regarding lucerne seed production: 1. That most farmers regard lucerne as a catch crop. 2. The terrific influence climatic conditions have on seed yield.
openaire +2 more sources