Results 81 to 90 of about 202,889 (355)

Serial amplification of tau filaments using Alzheimer's brain homogenates and C322A or C322S recombinant tau

FEBS Letters, EarlyView.
We investigated the seeded assembly of 0N3R tau and two variants, C322A and C322S, designed to model the mutation landscape at residue 322, using Alzheimer's disease brain homogenates in a real‐time quaking‐induced conversion (RT‐QuIC) assay. The C322A variant formed filaments that partially resembled the paired helical filament (PHF) structure ...
Alessia Santambrogio, Sofia Lövestam, Michael A. Metrick II, Thomas Löhr, Peifeng Xu, Nicholas C. T. Gallagher, Bernardino Ghetti, Byron Caughey, Sjors H. W. Scheres, Michele Vendruscolo   +9 more
wiley   +1 more source

The pattern and distribution of deleterious mutations in maize [PDF]

, 2013
Most non-synonymous mutations are thought to be deleterious because of their effect on protein sequence. These polymorphisms are expected to be removed or kept at low frequency by the action of natural selection, and rare deleterious variants have been ...
Mezmouk, Sofiane, Ross-Ibarra, Jeffrey
core   +2 more sources

Accelerated Aging Test to Determine the Vigor of Mungbean Seeds

Journal of Agricultural Science, 2019
The use of good quality seeds is fundamental for proper establishment of a crop. In this way, for more precise determination of seed quality, vigor tests are performed in addition to the germination test. These tests enable the selection of the best lots for commercialization and planting.
Rogério Lamim Silva Junior, A. D. V. Souza, Katiane Santiago Silva Benett, Nei Peixoto, Natália Arruda, Luciana Maria da Silva   +5 more
openaire   +2 more sources

ACSS2 involved in acetyl‐CoA synthesis regulates skeletal muscle function

FEBS Letters, EarlyView.
The enzyme acyl‐coenzyme A synthetase short‐chain family member‐2 (ACSS2) catalyzes the conversion of acetate to acetyl‐CoA, but its function in skeletal muscle is unclear. We studied ACSS2 deficiency in mouse and fly models. Skeletal muscle from the mouse model showed atrophic fibers, excess lipid, and depleted NADH.
Mekala Gunasekaran, Gloriana Campos, Natalya M. Wells, Khanhlinh Lambuu, Isabelle Draper, Christina A. Pacak, Peter B. Kang   +6 more
wiley   +1 more source

Control of corn diseases in Illinois [PDF]

, 1931
"In cooperation with Office of Cereal Crops and Diseases, Bureau of Plant Industry, U.S. Department of Agriculture.
Holbert, James R., Koehler, Benjamin
core  

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Pengaruh Penyimpanan Jangka Panjang (Long Term) Terhadap Viabilitas Dan Vigor Empat Galur Benih Inbred Jangung [PDF]

, 2013
Seed corn are orthodox seeds quite resistant to drying and low temperature storage. On optimal storage conditions, will be able to orthodox seeds stored for several years.
Hakim, N. A. (Nurman), Kartahadimaja, J. (Jaenudin), Syuriani, E. E. (Eka)   +2 more
core  

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Classification of West Indian gherkin seeds vigor by respiratory activity

Revista Ciência Agronômica
Seed companies increasingly need to obtain rapid and reliable results on seed quality. In this context, this study aimed at verifying the efficiency of CO2 measurement for classifying West Indian gherkin (Cucumis anguria L.) seed vigor, using three seed ...
Moadir de Sousa Leite, Tiago de Sousa Leite, Salvador Barros Torres, Caio César Pereira Leal, Rômulo Magno Oliveira de Freitas   +4 more
doaj   +1 more source

Winter Survival of Grasses and Legumes in Subarctic Alaska as Related to Latitudinal Adaptation, Pre-Winter Storage of Food Reserves, and Dry-Matter Concentration in Overwintering Tissues [PDF]

, 1993
similar experiments, were to (a) compare winter hardiness in subarctic Alaska of numerous plant species and ecotypes from various latitudinal sources within most species, and (b) seek a better understanding of certain aspects of pre-winter ...
Klebesadel, Leslie J.
core