Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Effect of agricultural practices on N2O emissions from Malagasy soils [PDF]
, 2007 Emissions of nitrous oxide (N20) are of concern because of the role of this gas in the greenhouse effect. The agricultural practices may affect the rate of N20 emissions from soil.
Chapuis-Lardy, Lydie +8 more
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Effect of different sowing densities in mixed cultivation of blue lupin (Lupinus angustifolius) with spring crops on yield and quality [PDF]
, 2008 The aim of this investigation was to optimise the yield percentage of blue lupins in mixed cropping systems. Field experiments were conducted at two locations in Northern Germany (Institute of Organic Farming near Hamburg and Institute of Plant and Soil ...
Aulrich, Karen +3 more
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Incidence de la densité de semis sur le rendement, les composantes du rendement et la croissance du blé dans la région du Mugamba (Burundi) [PDF]
Tropicultura, 1988 Effect of seeding rate on yield, yield components and vegetative growth of wheat in the Mugamba region (Burundi). Thirty one trials were carried out in the farmers' fields in the Mugamba area during the 1985 second crop growing season in order to study ...
Schalbroeck, JJ., Baragengana, R.
doaj
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Selective lasing in multimode periodic and non-periodic nanopillar waveguides
, 2006 We investigate the lasing action in coupled multi-row nanopillar waveguides of periodic or fractal structure using the finite difference time domain (FDTD) method, coupled to the laser rate equations. Such devices exhibit band splitting with distinct and
Akahane +25 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
A MATHEMATICAL PROGRAMMING MODEL FOR OPTIMAL MANAGEMENT ZONE DELINEATION IN PRECISION AGRICULTURE [PDF]
The identification of optimal management zones, including optimal uniform grid size, is a complex issue central to the successful implementation of variable rate input application.
Dillon, Carl R.
core +1 more source