Results 231 to 240 of about 327,495 (306)

Genomic identification of direct seeding and evolutionary lineages by combining heterogeneous genomic resources. [PDF]

BMC Biol
Tschan JN, Reutimann O, Fior S, Cornille A, Roman A, Ursu TM, Widmer A, Fischer MC.   +7 more
europepmc   +1 more source

Implementation of Drug‐Induced Rhabdomyolysis and Acute Kidney Injury in Microphysiological System

Advanced Functional Materials, EarlyView.
A modular Muscle–Kidney proximal tubule‐on‐a‐chip integrates 3D skeletal muscle and renal proximal tubule tissues to model drug‐induced rhabdomyolysis and acute kidney injury. The coculture system enables dynamic tissue interaction, functional contraction monitoring, and quantification of nephrotoxicity, revealing drug side effect‐induced metabolic ...
Jaesang Kim, Zhuo Feng Lee, Gi‐Dong Sim, Sejoong Kim, Jessie S. Jeon   +4 more
wiley   +1 more source

4R-tau seeding activity reveals molecular subtypes in progressive supranuclear palsy. [PDF]

Nat Commun
Martinez-Valbuena I, Lee S, Santamaria E, Fernández-Irigoyen J, Forrest SL, Zampar S, Li J, Tanaka H, Couto B, Gil D Reyes N, Qamar SH, Karakani AM, Kim A, Senkevich K, Rogaeva E, Fox SH, Tartaglia MC, Visanji NP, Ingelsson M, Andrews T, Lang AE, Kovacs GG.   +21 more
europepmc   +1 more source

A Bespoke Programmable Interpenetrating Elastomer Network Composite Laryngeal Stent for Expedited Paediatric Laryngotracheal Reconstruction

Advanced Functional Materials, EarlyView.
A programmable interpenetrating double‐network architecture, created via 3D‐TIPS printing and resin infusion, synergistically combines thermoplastic and thermosetting elastomers to balance structural rigidity and surface softness—crucial for paediatric laryngeal stents.
Elizabeth F. Maughan, Lei Wu, Dong Zhang, Linxiao Wu, Graca Ferreira Vaz Pinto Mendes, Wanqiao J. Tu, Heping Ma, Toby J. Proctor, Colin R. Butler, Thomas Kjærgaard, Mark W. Lowdell, Martin A. Birchall, Robert E. Hynds, Richard Hewitt, Wenhui Song   +14 more
wiley   +1 more source

Fluorescent Nanodiamonds Based Theranostic Platform for pH‐Sensitive Drug Delivery and Quantum Sensing

Advanced Functional Materials, EarlyView.
A multifunctional nanodiamond platform enables pH‐triggered Diazoxide (DZX) delivery and quantum sensing of subcellular radical dynamics in triple‐negative breast cancer cells. Diamond relaxometry revealed reduced lysosomal radicals during DZX‐induced mitochondrial radical elevation, providing insights into redox modulation and organelle‐ resolved ...
Kaiqui Wu, Siyu Fan, Yue Zhang, Willem Woudstra, Thomas Mulder, Laurens Boscher Navarro, Jur van Dijken, Katja Loos, Romana Schirhagl   +8 more
wiley   +1 more source

When Proteins Go MAD-Misfolded, Amplified, Detected: Advances in α-Synuclein Pathophysiology and RT-QuIC Detection. [PDF]

Mol Neurobiol
Labajová N, Polák A, Cehlár O, Križan P, Hritz J, Kolisek M, Škorvánek M, Škrabana R, Kovačech B, Žilka N.   +9 more
europepmc   +1 more source

Unleashing the Power of Machine Learning in Nanomedicine Formulation Development

Advanced Functional Materials, EarlyView.
A random forest machine learning model is able to make predictions on nanoparticle attributes of different nanomedicines (i.e. lipid nanoparticles, liposomes, or PLGA nanoparticles) based on microfluidic formulation parameters. Machine learning models are based on a database of nanoparticle formulations, and models are able to generate unique solutions
Thomas L. Moore, Cristiano Pesce, Antonietta Greco, Claudia Pisante, Greta Avancini, Valentina Di Francesco, Yosi Shamay, Paolo Decuzzi   +7 more
wiley   +1 more source

Oral Transmission of Classical Bovine Spongiform Encephalopathy in ARR/ARR Sheep. [PDF]

Emerg Infect Dis
Huor A, Lantier F, Douet JY, Lugan S, Aron N, Mesic C, Cassard H, Barrio T, Simmons H, Lantier I, Andreoletti O.   +10 more
europepmc   +1 more source

Complex Cryptographic and User‐Centric Physically Unclonable Functions Enabled by Strain‐Sensitive Nanocrystals via Selective Ligand Exchange

Advanced Functional Materials, EarlyView.
This study investigates electromechanical PUFs that improve on traditional electric PUFs. The electron transport materials are coated randomly through selective ligand exchange. It produces multiple keys and a key with motion dependent on percolation and strain, and approaches almost ideal inter‐ and intra‐hamming distances.
Seungshin Lim, Hanseok Seo, Taesung Park, Byung Ku Jung, Junhyeok Park, Young Kyun Choi, Dae Yang Oh, Soong Ju Oh   +7 more
wiley   +1 more source

Comparative flow cytometry immunophenotyping of ASCs expanded in conventional flasks versus automated bioreactors. [PDF]

Front Cell Dev Biol
Alipour H, Ren G, Sørensen MB, Aghazadeh S, Xuan Z, Dardmeh F, Porsborg SR, Fink T, Peng Q.   +8 more
europepmc   +1 more source