Results 81 to 90 of about 83,118,583 (348)
Is There an Internal Link between Seeing a Human and Seeing One to Whom Moral Consideration Is Due?
Is There an Internal Link between Seeing a Human and Seeing One to Whom Moral Consideration Is ...
Ariso Salgado, José María
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The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
, 2013 In the fable by Rumi, six blind men seeking information as to what an elephant looks like, lays their hands on a different part of the animal’s body and based on the evidence deduce that the elephant is like the part that they are touching.
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Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Seeing the Salzburgers in their Books
Theological Librarianship, 2018 The “Salzburger Collection” that once belonged to the group of pietist Lutherans who emigrated from Salzburg, Austria to Ebenezer, Georgia in 1734 and is now preserved at the Crumley Archives in Columbia, SC, contains 160 books printed 1615-1824.
Timothy Scott Reeves
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Mahkemelerin McDonaldlaşması ve McMahkemeler
Anadolu Üniversitesi Hukuk Fakültesi Dergisi, 2015 Uyuşmazlıkların resmi çözümünde başvurulan esas yer, diğer alternatif çözüm mekanizmalarının dışında, mahkemelerdir. Modern hukuk, formel karakteri ile bilinmekte ve bu istenir bir özellik olarak sunulmaktadır. Uyuşmazlıkları çözerken bu hukuku uygulayan
Murat Burak Aydın
doaj
Seeing Color, Seeing Emotion, Seeing Moral Value [PDF]
, 2016 Defenders of moral perception have famously argued that seeing value is relevantly similar to seeing color. Some critics think, however, that the analogy between color-seeing and value-seeing breaks down in several crucial respects.
De Mesel, Benjamin
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Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source