Results 91 to 100 of about 1,762,979 (356)
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
Frontiers in PsychologyObjectiveThis study aims to disclose and compare meat consumer segments in Switzerland and Vietnam, which differ in terms of their socioeconomic and cultural settings (the former is a developed country, and the latter is an emerging one) to develop a set
Mathilde Delley +10 more
doaj +1 more source
FEBS Letters, EarlyView.In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker +8 more
wiley +1 more source
Impact of Wolf Thresholding on Background Subtraction for Human Motion Detection
CompilerSeries of motion detection based on background subtraction there is an image segmentation stage. Thresholding is a common technique used for the segmentation process. There are two types that can be used in thresholding techniques namely local and global.
Elindra Ambar Pambudi +1 more
doaj +1 more source
THE MARKET CONCEPT OF THE XXI CENTURY: A NEW APPROACH TO CONSUMER SEGMENTATION
Vestnik MGIMO-Universiteta, 2016 World economic development in the 21st century keeps tendencies and contradictions of the previous century. Economic growth in a number of the countries and, as a result, growth of consumption adjoins to an aggravation of global problems of the present ...
M. I. Sokolova
doaj +1 more source
Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells
FEBS Letters, EarlyView.Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan +2 more
wiley +1 more source
Skin Segmentation, Skull Segmentation, and Mesh Generation Tool of Medical Image [PDF]
, 2014 The development of information and computer technology (ICT) has reached to various fields in the world, one of them is medical field. There are new methods of medication and diagnoses currently based on ICT, like MRI and CT Scanner.
Liliana, L. (Liliana) +1 more
core
, 2017 Automated segmentation approaches are crucial to quantitatively analyze large-scale 3D microscopy images. Particularly in deep tissue regions, automatic methods still fail to provide error-free segmentations.
Bartschat, Andreas +6 more
core +1 more source
FEBS Letters, EarlyView.The Arabidopsis mutants hls1 hlh1 and amp1 lamp1 exhibit pleiotropic developmental phenotypes. Although the functions of the causative genes remain unclear, they act in the same genetic pathway and are thought to generate non‐cell‐autonomous signals.
Takashi Nobusawa, Makoto Kusaba
wiley +1 more source
Advances in Dermatology and Allergology, 2014 Segmental neurofibromatosis or type V neurofibromatosis is a rare genodermatosis characterized by neurofibromas, café-au-lait spots and neurofibromas limited to a circumscribed body region. The disease may be associated with systemic involvement and malignancies. The disorder has not been reported yet in the Polish medical literature.
Michał Sobjanek +4 more
openaire +6 more sources