Results 91 to 100 of about 537,692 (296)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Journal of ImagingAccurate and comparable annual mapping is critical to understanding changing vegetation distribution and informing land use planning and management. A U-Net convolutional neural network (CNN) model was used to map natural vegetation and forest types ...
Tony Boston +2 more
doaj +1 more source
Automatic segmentation variability estimation with segmentation priors
Medical Image Analysis, 2018 Segmentations produced manually by experts or by algorithms are subject to variability, as they depend on many factors, e.g., the structure of interest, the resolution, contrast and quality of the images, and the expert experience or the algorithmic method.
L. Joskowicz +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Fractional Lévy Stable Motion from a Segmentation Perspective
Fractal and FractionalThe segmentation analysis of the Golding–Cox mRNA dataset clarifies the description of these trajectories as a Fractional Lévy Stable Motion (FLSM). The FLSM method has several important advantages.
Aleksander A. Stanislavsky +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Frontiers in Cardiovascular MedicineBackgroundSegmentation of cardiac structures is an important step in evaluation of the heart on imaging. There has been growing interest in how artificial intelligence (AI) methods—particularly deep learning (DL)—can be used to automate this process ...
Turki Nasser Alnasser +14 more
doaj +1 more source
Enabling user‐guided segmentation and tracking of surface‐labeled cells in time‐lapse image sets of living tissues [PDF]
, 2012 David N. Mashburn +3 more
openalex +1 more source