Results 91 to 100 of about 729,834 (302)

Multi-scale Gaussian representation and outline-learning based cell image segmentation [PDF]

, 2013
BACKGROUND: High-throughput genome-wide screening to study gene-specific functions, e.g. for drug discovery, demands fast automated image analysis methods to assist in unraveling the full potential of such studies.
Rämö, P., Mario Emmenlauer, Ruusuvuori, P., Pekka Ruusuvuori, Dehio, C., Yli-Harja, O., Christoph Dehio, Emmenlauer, M., Olli Yli-Harja, Farhan, M., Muhammad Farhan, Pauli Rämö   +11 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Improved Segmentation of Infant Retinal Images and Quantitative Vascular Analysis

IEEE Access
Retinopathy of Prematurity is a leading cause of visual impairment in preterm infants and is characterized by dilation and tortuosity of the retinal blood vessels in the plus disease stage.
Ying Wang, Xiaoyu Zheng, Chunlei He, Jianfeng Zhang, Shoujun Huang   +4 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Integration of feature distributions for colour texture segmentation [PDF]

, 2004
This paper proposes a new framework for colour texture segmentation and determines the contribution of colour and texture. The distributions of colour and texture features provides the discrimination between different colour textured regions in an ...
P.F. Whelan, Nammalwar, Padmapriya, Ghita, Ovidiu, O. Ghita, Whelan, Paul F., P. Nammalwar   +5 more
core   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Hypothesis-based image segmentation for object learning and recognition [PDF]

, 2010
Denecke A. Hypothesis-based image segmentation for object learning and recognition. Bielefeld: Universität Bielefeld; 2010.This thesis addresses the figure-ground segmentation problem in the context of complex systems for automatic object recognition as ...
Denecke, Alexander
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Hierarchical Models for Image Segmentation: from Color to Texture [PDF]

, 2008
Segmentation is a low-level processing aimed at the partition of an image in disjoint regions, each one homogeneous with respect to some properties like intensity, texture, shape, etc.
Gaetano, Raffaele
core   +1 more source