Results 201 to 210 of about 1,774,351 (250)

Impact of Osilodrostat on Health‐Related Quality of Life in Cushing's Disease: Analysis of Patient‐Reported Outcomes From the Phase III LINC 3 and LINC 4 Clinical Trials

open access: yesClinical Endocrinology, Volume 105, Issue 4, Page 452-463, October 2026.
ABSTRACT Objective Evaluate the effects of osilodrostat short‐ and long‐term treatment on health‐related quality of life (HRQoL) in Cushing's disease. Design LINC 3 and LINC 4 studies (pooled analysis). Patients 185 patients (mean baseline total scores: Cushing's Quality of Life [CushingQoL], 44.0; Beck Depression Inventory II [BDI‐II], 15.6; EuroQol ...
John Newell‐Price   +6 more
wiley   +1 more source

The Rising Tide Lifts Some Interest Rates: Climate Change, Natural Disasters, and Loan Pricing

open access: yesThe Journal of Finance, Volume 81, Issue 5, Page 2933-2984, October 2026.
ABSTRACT Banks adjust loan spreads after observing natural disasters linked to climate change. We isolate this updating process by identifying loans to borrowers at risk of, but not directly affected by, such disasters. Loan spreads for these borrowers spike in both primary and secondary markets, while no such updating occurs for non–climate‐related ...
RICARDO CORREA   +3 more
wiley   +1 more source

Dam Management in the Era of Climate Change

open access: yesMathematical Finance, Volume 36, Issue 4, Page 870-895, October 2026.
ABSTRACT Climate change has a dramatic impact, particularly by concentrating rainfall into a few short periods, interspersed with long dry spells. In this context, the role of dams is crucial. We consider the optimal control of a dam, where the water level must neither exceed a designated safety threshold nor fall below a minimum level to ensure ...
Cristina Di Girolami   +3 more
wiley   +1 more source

Quantifying the Role of 3D Fault Geometry Complexities on Slow and Fast Earthquakes

open access: yesGeophysical Research Letters, Volume 53, Issue 18, 28 September 2026.
Abstract Traditional models of slow slip events (SSEs) oversimplify fault geometry, although imaging shows subduction faults are segmented and complex. We examine how fault interactions control slip behavior using 3D quasi‐dynamic simulations of two parallel faults with uniform rate‐weakening friction accelerated by hierarchical matrices.
J. Cheng   +4 more
wiley   +1 more source

Along‐Strike Coupling Heterogeneity in Cascadia's Slow‐Slip Zone Constrained by GNSS and Reduced‐Order Rate‐And‐State Friction Modeling

open access: yesGeophysical Research Letters, Volume 53, Issue 18, 28 September 2026.
Abstract Slow slip events (SSEs) in the Cascadia subduction zone exhibit along‐strike segmentation, where the central segment has longer recurrence intervals but smaller moments. We quantify the controls on this variability by combining geodetic inter‐SSE coupling inversion with Bayesian inference of a quasi‐dynamic rate‐and‐state friction SSE‐cycle ...
Yohai Magen   +2 more
wiley   +1 more source

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