Results 91 to 100 of about 307,198 (323)
Molecular Oncology, EarlyView.MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin +14 more
wiley +1 more source
cSeiz: An Edge-Device for Accurate Seizure Detection and Control for Smart Healthcare [PDF]
arXiv, 2019 Epilepsy is one of the most common neurological disorders affecting up to 1% of the world's population and approximately 2.5 million people in the United States. Seizures in more than 30% of epilepsy patients are refractory to anti-epileptic drugs. An important biomedical research effort is focused on the development of an energy efficient implantable ...
arxiv
Seizure-Related Head Injuries: A Narrative Review
Brain SciencesEpilepsy is one of the most common neurological diseases. Epileptic seizures very often result in head injuries that may lead to many adverse consequences, both acute and chronic. They contribute to the need for hospitalization, modification of treatment,
Sebastian Piwowarczyk +5 more
doaj +1 more source
Molecular Oncology, EarlyView.NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi +5 more
wiley +1 more source
Ictal and Post Ictal Impaired Consciousness due to Enhanced Mutual Information in Temporal Lobe Epilepsy [PDF]
arXiv, 2018 Seizure and synchronization are related to each other in complex manner. Altered synchrony has been implicated in loss of consciousness during partial seizures. However, the mechanism of altered consciousness following termination of seizures has not been studied well. In this work we used bivariate mutual information as a measure of synchronization to
arxiv
Epilepsia OpenObjective Epilepsy surgery is known to be underutilized. Machine learning‐natural language processing (ML‐NLP) may be able to assist with identifying patients suitable for referral for epilepsy surgery evaluation.
Sheryn Tan +15 more
doaj +1 more source
BiomedicinesEslicarbazepine acetate (ESL) is a third-generation antiepileptic drug indicated as monotherapy for adults with newly diagnosed epilepsy and as adjunctive therapy for the treatment of partial seizures.
Jaime Gonçalves-Sánchez +4 more
doaj +1 more source
Molecular Oncology, EarlyView.In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen +17 more
wiley +1 more source
Anti-seizure medication load is not correlated with early termination of seizure spread [PDF]
arXivAnti-seizure medications (ASMs) are the mainstay of treatment for epilepsy, yet their effect on seizure spread is not fully understood. Higher ASM doses have been associated with shorter and less severe seizures. Our objective was to test if this effect was due to limiting seizure spread through early termination of otherwise unchanged seizures.
arxiv