Results 141 to 150 of about 615,127 (352)

Drug-Inducible Gene Therapy Effectively Reduces Spontaneous Seizures in Kindled Rats but Creates Off-Target Side Effects in Inhibitory Neurons [PDF]

, 2023
Kyle A. Sullivan, Iuliia Vitko, K. L. Blair, Ronald P. Gaykema, Madison J. Failor, Jennifer M. San Pietro, Deblina Dey, John Williamson, Ruth L. Stornetta, Jaideep Kapur, Edward Perez‐Reyes   +10 more
openalex   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Amplitude-integrated electroencephalography for neonatal seizure detection. An electrophysiological point of view

Arquivos de Neuro-Psiquiatria
Seizures in the newborn are associated with high morbidity and mortality, making their detection and treatment critical. Seizure activity in neonates is often clinically obscured, such that detection of seizures is particularly challenging.
Sebastián Gacio
doaj   +1 more source

Neonatal brain MRI and short-term outcomes after acute provoked seizures [PDF]

, 2023
Yi Li, Aaron Scheffler, A. James Barkovich, Taeun Chang, Catherine J. Chu, Shavonne L. Massey, Nicholas S. Abend, Monica E. Lemmon, Cameron Thomas, Adam L. Numis, Linda S. Franck, Elizabeth A. Rogers, Andrew L. Callen, Charles E. McCulloch, Renée A. Shellhaas, Hannah C. Glass   +15 more
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

The Predictive Role of Neutrophil-to-LymPhocyte Ratio in Seizure Recurrence in Patients with Epilepsy

Acta Neurologica Taiwanica
Background: The aim of this retrospective study was to investigate the importance of leukocyte, neutrophil, lymphocyte, and neutrophil/lymphocyte (NLR) ratios in epileptic seizure recurrence and whether there is a relationship between them.
Elif Simin Issı, Demet İlhan Algın, Oğuz Osman Erdinç   +2 more
doaj   +1 more source

Sleep Related Hypermotor Seizures with a Right Parietal Onset [PDF]

, 2015
Steve A. Gibbs, Michela Figorilli, Giuseppe Casaceli, Paola Proserpio, Lino Nobili   +4 more
openalex   +1 more source

Design of a Dense Layered Network Model for Epileptic Seizures Prediction with Feature Representation [PDF]

, 2022
Summia Parveen, Sumit Kumar, M. Prabhavathy, Kingsly Jabakumar, R Senthil Ganesh   +4 more
openalex   +1 more source

A unified model for Duchenne muscular dystrophy gene involvement in cancer: context‐dependent tumour suppression and oncogenicity

FEBS Open Bio, EarlyView.
We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado, Leanne Jones, Sonika Divakar, Michael Naidoo, Karen Anthony   +4 more
wiley   +1 more source

Cow’s milk in infant diet is a risk factor for hypocalcemic seizures

Эпилепсия и пароксизмальные состояния
Background. Seizures are common in infants due to the inherent sensitivity of the developing brain to various insults, with metabolic alterations being a ordinary cause. Among these, hypocalcemia is a prevalent factor.
K. Arunkarthik, A. Thasma Santhanakrishnan   +1 more
doaj   +1 more source