Results 201 to 210 of about 263,244 (268)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Association of respiratory viral detection with complex febrile seizures and hospitalisation in children after the COVID-19 pandemic: a retrospective observational study. [PDF]

BMJ Paediatr Open
Song HY, Paek SH, Kwon JH, Park SH, Kim MJ, Byun YH, Kim JH, Kim SH.   +7 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

A 4-Year-Old Bahraini Girl With Developmental Delay and Epilepsy of Infancy With Migrating Focal Seizures Associated With KCNT1 Gene Mutation. [PDF]

Am J Case Rep
AlHadi NE, Albuainain HM, Jadah RH.
europepmc   +1 more source

Multiple Carboxylase Deficiency in an Infant Presenting With Severe Metabolic Acidosis and Sepsis-Like Features: A Case Report and Literature Review. [PDF]

Clin Case Rep
Rehman T, Saeed R, Rauf MAA, Asif L, Junaid M, Khalid M, Ali RN, Ali U, Segawa F.   +8 more
europepmc   +1 more source

Contrast-induced encephalopathy presenting with refractory status epilepticus following endovascular coiling of an intracranial aneurysm: A case report and literature review. [PDF]

J Int Med Res
Jing L, Zhao Z, Wan S, Wang M, Shao G.
europepmc   +1 more source

Ictal gamma increase shows preferential localization to seizure onset contacts in stereoelectroencephalography. [PDF]

Front Neurol
Jian Y, Hou K, Zhang W, Wang L, Wang J.
europepmc   +1 more source

Epilepsy associated with <i>SYNGAP1</i> gene variants: clinical features of six cases and a literature review. [PDF]

Front Pediatr
Zhang W, Wang Y, Xu K, Wang L, Wang Y, Chen G, Ma Y.   +6 more
europepmc   +1 more source