Results 71 to 80 of about 307,198 (323)
This study demonstrates that KRAS and GNAS mutations are more prevalent in patients with resected intraductal papillary mucinous neoplasms (IPMN) compared to those under clinical surveillance. GNAS mutations significantly differ between the two patient cohorts, indicating that their absence may serve as a potential biomarker to support conservative ...
Christine Nitschke+12 more
wiley +1 more source
Predicting the spatiotemporal diversity of seizure propagation and termination in human focal epilepsy [PDF]
Recent studies have shown that seizures can spread and terminate across brain areas via a rich diversity of spatiotemporal patterns. In particular, while the location of the seizure onset area is usually in-variant across seizures in a same patient, the source of traveling (2-3 Hz) spike-and-wave discharges (SWDs) during seizures can either move with ...
arxiv +1 more source
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić+31 more
wiley +1 more source
Electroencephalographic Slowing: A Source of Error in Automatic Seizure Detection [PDF]
Although a seizure event represents a major deviation from a baseline electroencephalographic signal, there are features of seizure morphology that can be seen in non-epileptic portions of the record. A transient decrease in frequency, referred to as slowing, is a generally abnormal but not necessarily epileptic EEG variant.
arxiv
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu+3 more
wiley +1 more source
How important is the seizure onset zone for seizure dynamics? [PDF]
Purpose: Research into epileptic networks has recently allowed deeper insights into the epileptic process. Here we investigated the importance of individual network nodes for seizure dynamics. Methods: We analysed intracranial electroencephalographic recordings of 86 focal seizures with different anatomical onset locations.
arxiv +1 more source
Clinical Characteristics of 5 Phenotypes of Coenzyme Q10 Deficiency
Researchers at Columbia University Medical Center, New York; University of Genoa, Italy; and University of Granada, Spain reviewed 149 cases of coenzyme Q10 (ubiquinone) deficiency, including their own cohort of 76 patients diagnosed from 1997-2010.
J Gordon Millichap
doaj +1 more source
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam+2 more
wiley +1 more source
Risk Factors for Epilepsy after Febrile Seizures
Investigators from Aristotle University of Thessaloniki, Greece, identified prognostic factors for subsequent epilepsy in a prospective study of 501 children with a first febrile seizure (FS).
J Gordon Millichap, John J Millichap
doaj +1 more source
Febrile seizure (FS) is the most common seizure disorder of childhood, and occurs in an age-related manner. FS are classified into simple and complex. FS has a multifactorial inheritance, suggesting that both genetic and environmental factors are causative. Various animal models have elucidated the pathophysiological mechanisms of FS.
openaire +3 more sources