Results 171 to 180 of about 4,960,323 (312)

An Integrated Artificial Intelligence Framework for Nanomedicine Engineering

Advanced Science, EarlyView.
This review outlines a closed‐loop AI ecosystem for nanomedicine engineering. By synergizing multimodal data harmonization, objective‐driven AI architectures, and automated high‐throughput validation, this “Design‐Make‐Test‐Analyze” (DMTA) workflow transforms traditional heuristic formulation into a predictive, self‐optimizing paradigm, accelerating ...
Meichen Dong, Qin Luo, Xinyi Ding, Chaoqi Lu, Ru Zhang, Qingqing Tan, Zhiqing Pang, Defang Ouyang, Dongsheng Li, Jiaxuan Xia, Jianxin Wang   +10 more
wiley   +1 more source

scH16S‐Seq Maps Klebsiella pneumoniae‐Associated Myeloid States and Reveals a CD38–NAD Immunometabolic Axis That Impairs Lysosomal Acidification in Sepsis

Advanced Science, EarlyView.
Single‐cell host–bacterial 16S co‐sequencing (scH16S‐seq) integrates cell‐associated bacterial 16S‐derived signals with host transcriptomes to resolve bacterial signal‐enriched myeloid states in Klebsiella pneumoniae sepsis. Complementary pharmacological and genetic analyses define a CD38–NAD immunometabolic axis connecting mitochondrial bioenergetic ...
Yangguang Li, Yilong Yu, Fang Qin, Shenxing Li, Xuanheng Li, Peizhao Liu, Juanhan Liu, Haiqing Liu, Songqi Jing, Jianghao Zou, Sicheng Li, Jiayang Li, Tao Zheng, Yun Zhao, Jianan Ren, Xiuwen Wu   +15 more
wiley   +1 more source

Global Optimal Solving Algorithm for Power Distribution Based on Selective Harmonic Elimination in Cascaded H-Bridge Multilevel Inverters. [PDF]

Sensors (Basel)
Qian X, Hao J, Xiao J, Yang H, Zhang Q, Yuan Z.   +5 more
europepmc   +1 more source

Massively Multiplexed Photonic Chip With Cross‐Channel Fusion For Harmonized Biosensing

Advanced Science, EarlyView.
We introduce a transformative sensing platform integrating photonic multiplexing with over 10 000 sensors and a deep‐learning framework that combines domain adaptation and cross‐channel fusion for harmonized operation across heterogeneous chips. The platform achieves 99.3% identification accuracy and relative prediction errors of 10−4$^{-4}$ for ...
Ivan Saetchnikov, Elina Tcherniavskaia, Andreas Ostendorf, Anton Saetchnikov   +3 more
wiley   +1 more source

Comparison of ABBV-552 Safety and Pharmacokinetics in Healthy Asian and Western Adults. [PDF]

Clin Pharmacol Drug Dev
Miles N, McNamee B, Zadikoff C, Boiser J, Shebley M, Boinpally R.   +5 more
europepmc   +1 more source

High‐Efficiency InGaP‐on‐Insulator Microresonator Nonlinear Conversion and Entanglement Generation

Advanced Science, EarlyView.
Sulfur treatment of InGaP‐on‐Insulator (InGaP‐OI) significantly reduces surface roughness, passivates surface states, and lowers propagation loss at visible wavelengths, enabling efficient nonlinear frequency conversion and photon‐pair generation.
Xuefeng Li, Lillian Thiel, Yiming Pang, Amalu Shimamura, Lucas Wang, Joshua E. Castro, Max Meunier, Nicholas Lewis, John E. Bowers, Kevin L. Silverman, Richard P. Mirin, Galan Moody   +11 more
wiley   +1 more source

Harmonic analysis of radial pulse in traditional Chinese medicine: physiological alterations associated with hepatitis B and hepatitis C infections. [PDF]

Front Med (Lausanne)
Wu CH, Liao KF, Chen JJ, Wu H.
europepmc   +1 more source

Molecular Rectification: Mechanisms, Modulation Strategies, and Device Realization

Advanced Science, EarlyView.
This review focuses on molecular rectification, from its fundamental mechanisms and modulation strategies to device realization. It summarizes the theoretical framework, modulation strategies, fabrication techniques, characterization methods, and modeling and simulation of molecular rectifiers, while discussing challenges and future directions for ...
Junnan Guo, Shufan Song, Wenhui Fang, Jifeng Tang, Wenhao Li, Weikang Wu, Shishen Yan, Hui Li, Lishu Zhang   +8 more
wiley   +1 more source

<i>Fridericia chica</i> standardized extract combined with tocotrienol-enriched fraction from <i>Bixa orellana</i> promotes gastric mucosal protection: <i>in vitro</i> combination selection and <i>in vivo</i> evaluation. [PDF]

Pharm Biol
de Freitas AS, Sousa IMO, Favero FF, Oliveira JC, Pontes RDS, Campos AV, Magossi CG, Biccigo MG, Ruiz ALTG, de Carvalho JE, Foglio MA.   +10 more
europepmc   +1 more source

Meningeal Lymphatic LTBR Deficiency Links Spinal Cord Injury to Secondary Brain Pathology

Advanced Science, EarlyView.
Spinal cord injury (SCI) induces remote brain alterations beyond the injured spinal cord. This study links dysfunction of meningeal lymphatic vessels (mLVs) to neuroinflammation and neuronal injury after SCI. LTBR‐mediated lymphatic restoration improves meningeal lymphatic integrity and neurological outcomes, highlighting LTBR as a potential regulator ...
Yi Chen, Yu Tang, Chengpeng Hu, Xiaoyan Duan, LingXia Min, Boya Cong, Chao Ma, Mingliang Tan, Ya Luo, Pengfei Wei, Minpeng Xu, Zhou Feng, Jingming Hou   +12 more
wiley   +1 more source