Results 41 to 50 of about 4,960,323 (312)

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Selective Harmonic Elimination Modulation for HVDC Modular Multilevel Converter

, 2021
This paper proposes the application of a mixed selective harmonic elimination mitigation modulation algorithm to three-phase HVDC modular multilevel converters. Defining 1 the number of levels, two cases have been considered: t=65 and t=257.
Cimoroni M. G., Cecati C., Carlo Cecati, Concettina Buccella, Buccella C., Maria Gabriella Cimoroni   +5 more
core   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Generalized formulation of multilevel selective harmonic elimination PWM: Case I-Non-Equal DC Sources [PDF]

, 2006
The paper presents optimal solutions for eliminating harmonics from the output waveform of a multilevel staircase pulse-width modulation (PWM) method with non-equal dc sources.
Dahidah, M.S.A., Agelidis, V.G.
core  

Modified Quantum Particle Swarm Optimization For Selective Harmonic Elimination (SHE) in A Single-phase Multilevel Inverter

, 2021
The Multilevel Inverter (MLI) uses Selective Harmonic Elimination (SHE) of the Pulse Width Modulation (PWM) approach to tackle the fundamental harmonics with the elimination of selected lower harmonics.
Watada, Junzo, Hossain, Nafize Ishtiaque, Negash, Berihun Mamo, Alhitmi, Hitmi Khalifa, Islam, Jahedul, Meraj, Sheikh Tanzim, Biswas, Kallol, Vasant, Pandian M.   +7 more
core   +1 more source

Safety and Efficacy of GLP‐1 Receptor Agonists in Adults With Epilepsy, Obesity, and Type 2 Diabetes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Managing obesity in patients with epilepsy is complicated by the weight‐gaining properties of essential antiseizure medications (ASMs) such as valproate and pregabalin. We evaluated the safety and efficacy of initiating glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) in this population.
Hyoshin Son, Inyoung Hwang, Sang Won Lee, Yun Kim   +3 more
wiley   +1 more source

microRNA‐7‐5p and α‐Synuclein SAA Predict Parkinson's Disease Phenoconversion

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Corroborate blood neuron‐derived extracellular vesicle (NDEV) alpha‐synuclein (αSyn), the CSF αSyn seed amplification assay (αSyn‐SAA), and blood microRNA‐7‐5p (miR‐7‐5p) as markers for Parkinson's disease (PD) phenoconversion and determine if combining these markers would help select subjects who would be more likely to phenoconvert.
Shayan Zadegan, Praveen Velammal, Kanmani Muthiah, Madhu Jatty, Christopher Adams   +4 more
wiley   +1 more source

Noise Reduction for Modal Parameter Identification of the Measured FRFs Using the Modal Peak-Based Hankel-SVD Method

Shock and Vibration, 2020
The measured frequency response functions (FRFs) in the modal test are usually contaminated with noise that significantly affects the modal parameter identification.
Tianxu Zhu, Chaoping Zang, Gengbei Zhang
doaj   +1 more source

Microscale Patterning of Ultrahigh‐Viscosity Metallic‐Polymer Composites via Embedded Droplet Writing

Advanced Functional Materials, EarlyView.
A hybrid additive manufacturing platform integrates direct droplet writing of metallic composite with VAT photopolymerization to fabricate architected soft magnetic composites. This approach enables microscale patterning of high‐viscosity materials for programmable actuators, adaptive fluidic devices, and switchable adhesives, offering tunable ...
Yeowon Yoon, Jian Ni, Sungmo Park, Yang Xu, Yong Chen   +4 more
wiley   +1 more source