Results 201 to 210 of about 10,542,246 (288)

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

IMFrag: A Tool to Recognize In-Source Fragmentation in Ion Mobility-Enabled Data-Independent Acquisition Workflows. [PDF]

Anal Chem
Nguyen R, Anandkumar A, Rangel G, Liem J, Lin YS, Xu L.   +5 more
europepmc   +1 more source

Two‐Dimensional Quaternary Alloys of (RuMoVNb)Se2 for Superior Hydrogen Evolution Reaction Catalysis

Advanced Science, EarlyView.
Composition‐tuned (RuMoVNb)Se2 quaternary alloy nanosheets are synthesized via colloidal reactions. Incorporation of Ru into (MoVNb)Se2 ternary alloys results in more metallic electronic structures and significantly enhances their electrocatalytic activity for the hydrogen evolution reaction (HER) under alkaline, acidic, and neutral conditions.
Junaid Ihsan, Ju Yeon Kim, Irtiqa Mishal, Jun Hyeok Choi, Jeong Eun An, Youn Jun Choi, Doyeon Kim, In Hye Kwak, Gianvito Vilé, Ik Seon Kwon, Hong Seok Kang, Jeunghee Park   +11 more
wiley   +1 more source

Sheath-Liquid CE-MS Interface: A Robust Infusion Platform for Native IMS-MS Analysis of Protein Assemblies and Their Conformers. [PDF]

J Mass Spectrom
Pathak K, Brinkman D, Gomes FP.
europepmc   +1 more source

Polydopamine Nanoparticle‐Mediated Precise Near‐Infrared Optical Stimulation for Cognitive Enhancement

Advanced Science, EarlyView.
Polydopamine nanoparticles enable a precise, non‐genetic, and transcranial neuromodulation strategy via near‐infrared photothermal stimulation. By activating TRPV1 channels, this approach specifically enhances hippocampal gamma oscillations, thereby rescuing spatial memory deficits in models of perioperative neurocognitive disorder.
Yan‐Bo Zhou, Qiong Xue, Su‐Xuan Hou, Ke‐Yao Zhang, Wei‐Tong Pan, Ting‐Ting Zeng, Yu‐Ge Wang, Daqing Ma, Chenguang Zhao, Pan‐Miao Liu, Jian‐Jun Yang   +10 more
wiley   +1 more source

Protocol for the isolation and characterization of extracellular vesicles from human mesenchymal stromal cells. [PDF]

STAR Protoc
Collins A, Liddle J, Balsbaugh J, Walker J, Wanczyk H, Finck C, Saneh H.   +6 more
europepmc   +1 more source

Disrupting Helicobacter pylori Iron Homeostasis With Bismuth Nanodrug‐Mediated Nutritional Trap for Targeted Gastric Infection Therapy

Advanced Science, EarlyView.
A “nutritional trap” strategy centered on disrupting bacterial iron homeostasis is proposed. The synthesized Bi‐TP@FU (TBF) can target Helicobacter pylori, interfere with the bacterial iron uptake and utilization processes to disrupt its iron homeostasis, induce bacterial death, and meanwhile preserve the balance of the intestinal flora.
Tianye Fang, Jinzhe Tong, Feng Feng, Cong Liu, Chang Shu, Jiaying Zhu, Shibo Zhang, Shuyue Deng, Wanchao Zuo, Yuhan Song, Jun Yang, Yanmin Ju, Yingying Xing, Jianjun Dai   +13 more
wiley   +1 more source

Rapid Classification of Coffee Varieties Using Single-Bean Hot Gas Extraction Ion-Mobility Spectrometry with Machine Learning. [PDF]

ACS Meas Sci Au
Prayoga NA, Raju CM, Urban PL.
europepmc   +1 more source

A Phosphorylation‐Induced Micellization Switch in the Low‐Complexity Domain of TDP‐43

Advanced Science, EarlyView.
Phosphorylation of TAR DNA‐binding protein's 43 kDa (TDP‐43) low‐complexity domain by casein kinase 1 delta (CK1δ) acts as a molecular switch, redirecting its self‐assembly from macroscopic phase separation toward finite‐sized, spherical block‐copolymer micelles of ∼30 nm.
Rodrigo F. Dillenburg, Anastasia Lopatina, Hao Ruan, Tom Scheidt, Simone Mosna, Emre Pekbilir, Julia Bieber, Frank Schäfer‐Depoix, Katharina Landfester, Carla Schmidt, Martin M. Möckel, Svenja Morsbach, Friederike Schmid, Dorothee Dormann, Lukas Stelzl, Martin Girard, Edward A. Lemke   +16 more
wiley   +1 more source

Analysis of Human Placental Tissues Using Gas Chromatography High Resolution Accurate Mass Spectrometry to Characterize Exposure to a Range of Semivolatile Organic Compounds. [PDF]

Expo Health
Misselwitz M, Herkert NJ, Lee Ferguson P, Stapleton HM.   +3 more
europepmc   +1 more source