Results 101 to 110 of about 3,170,900 (297)
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Selection index theory for populations under directional and stabilizing selection. [PDF]
Genet Sel Evol, 2023 Wellmann R.
europepmc +1 more source
TOPPING INFORMAL RISK POOLING WITH INDEXED INSURANCE: A VAR APPLICATION [PDF]
Value at Risk (VaR) is applied to investigate the potential of incentives for member selection in an index insuring mutual group of farmers. Member selection could have far reaching impications of introducing indexed insurance in smallholder economies ...
Miriti, M'Kiaira Kimathi
core +1 more source
The brittleness index in hydraulic fracturing [PDF]
, 2015 We present a new definition of a brittleness index which is used as a criterion for candidate selection of rock intervals for hydraulic fracturing. The new index is a combination of material strength parameters and insitu stresses. It was derived from an
Atkinson, C, Papanastsiou, P
core
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Мелиорация и гидротехникаPurpose: to study the productive potential of new early-maturing maize hybrids of FAO 150–160, selected by All-Russian Research Institute of Irrigated Agriculture, under the boghara conditions, in the north-west of Volgograd region.
Elena V. Chugunova +2 more
doaj +1 more source
Analysis of dog breed diversity using a composite selection index. [PDF]
Sci Rep, 2023 Hsu WT, Williamson P, Khatkar MS.
europepmc +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
The Big Mac Standard: A Statistical Illustration [PDF]
We demonstrate a statistical procedure for selecting the most suitable empirical model to test an economic theory, using the example of the test for purchasing power parity based on the Big Mac Index.
Fujiki, Hiroshi, Kitamura, Yukinobu
core