Results 161 to 170 of about 3,170,900 (297)

Use of multi-trait principal component selection index to identify fall armyworm (<i>Spodoptera frugiperda</i>) resistant maize genotypes. [PDF]

Front Plant Sci
Wambi W, Makumbi D, Asea G, Zeleke H, Bruce AY, Wakgari M, Kwemoi DB, Prasanna BM.   +7 more
europepmc   +1 more source

Selection index in the study of adaptability and stability in maize. [PDF]

ScientificWorldJournal, 2014
Lunezzo de Oliveira R, Garcia Von Pinho R, Furtado Ferreira D, Miranda Pires LP, Costa Melo WM.   +4 more
europepmc   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Grey preferences selection index with trimmed group preference for evaluating university dormitory renovation design. [PDF]

Sci Rep
Ren J, Esangbedo MO.
europepmc   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Enhancing grapevine breeding efficiency through genomic prediction and selection index. [PDF]

G3 (Bethesda)
Brault C, Segura V, Roques M, Lamblin P, Bouckenooghe V, Pouzalgues N, Cunty C, Breil M, Frouin M, Garcin L, Camps L, Ducasse MA, Romieu C, Masson G, Julliard S, Flutre T, Le Cunff L.   +16 more
europepmc   +1 more source

Effects of selection index coefficients that ignore reliability on economic weights and selection responses during practical selection. [PDF]

Asian-Australas J Anim Sci, 2018
Togashi K, Adachi K, Yasumori T, Kurogi K, Nozaki T, Onogi A, Atagi Y, Takahashi T.   +7 more
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

A proposed selection index for jersey cattle in zimbabwe. [PDF]

ISRN Vet Sci, 2013
Missanjo E, Imbayarwo-Chikosi V, Halimani T.   +2 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source