Results 41 to 50 of about 957,890 (293)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Maleimido substituted aromatic cyclotriphosphazenes [PDF]

, 1985
4-Aminophenoxy cyclotriphosphazenes are reacted with maleic anhydride to produce maleamic acids which are converted to the maleimides. The maleimides are polymerized. By selection of starting materials (e.g., hexakis amino or trisaminophenoxy-trisphenoxy-
Fohlen, G. M., Kumar, D., Parker, J. A.
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Suitability of drought tolerance indices for selecting alfalfa (Medicago sativa L.) genotypes under organic farming in Austria [PDF]

, 2012
In eastern Austria, alfalfa is usually grown as a rainfed crop in crop rotations in organic farming systems, where year-to-year rainfall fluctuations cause different levels of drought stress. To identify the suitability of different alfalfa genotypes and
Ardakani, M. Reza, Friedel, Juergen K., Moghaddam, Ali, Pietsch, Gabriele, Raza, Amir, Vollmann, Johann, Wanek, Wolfgang   +6 more
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Magnitude and direction of association for yield and yield attributes in groundnut (Arachis hypogaea L.) [PDF]

Electronic Journal of Plant Breeding, 2014
Correlation analysis among kernel yield and its component characters was carried out to identify the selection indices in BC1F1 populations of two crosses viz., CO 7 × GPBD 4 and CO 7 × COG 0437.
R. Prabhu, N. Manivannan, A. Mothilal and S.M. Ibrahim
doaj  

Genetic parameters and selection of biofortified lettuce genotypes based on selection indices

Revista Brasileira de Engenharia Agrícola e Ambiental, 2021
Obtaining biofortified vegetables with an emphasis on lettuce is a tool to improve the nutritional status of the population. Selection indices can maximize the simultaneous selection of good agronomic traits and high carotenoid levels.
Luciana A. de Sousa, Gabriel M. Maciel, Fernando C. Juliatti, Igor F. Beloti, Daniel B. O. Cardoso, Ana C. S. Siquieroli   +5 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Selection Indices for Milk Traits in Holstein–Friesian Cows: A Comparison of Relative Economic Value Methods

Ruminants
Selection indices enhance dairy cattle breeding by optimizing multiple traits simultaneously. This study analyzed 2181 lactation records from Holstein–Friesian cows at Sakha Experimental Farm, Egypt, to evaluate selection indices for 305-day milk yield ...
Ahmed Mohamed Hussein, Fage Farrag, Mohamed Nageib El-Arian, El-Shafe Abdel Kader Omer, Adel Salah Khattab, Oludayo Michael Akinsola, Thiruvenkadan Aranganoor Kannan   +6 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source