Results 101 to 110 of about 14,412,361 (303)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Embracing diversity during researcher evaluation in the academic scientific environment

Frontiers in Education, 2023
Rodrigo Riera, Rodrigo Riera, Raúl Quesada-Cabrera, Raúl Quesada-Cabrera, Alejandro Martínez, Sam Dupont, Sam Dupont   +6 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Bayesian Nonparametric Construction of the Fleming-Viot Process with Fertility Selection [PDF]

This paper provides the construction in a Bayesian setting of the Fleming-Viot measurevalued process with diploid fertility selection and highlights new connections between Bayesian nonparametrics and population genetics.
Stephen G. Walker, Matteo Ruggiero
core  

The PLATO field selection process

Astronomy & Astrophysics
The PLanetary Transits and Oscillations of stars (PLATO) mission will begin its four-year nominal mission in early 2027 by monitoring its Long-duration Observation Phase field at South (LOPS2) for at least two years continuously. The primary aim of PLATO
Nascimbeni V., Piotto G., Granata V., Marinoni S., Marrese P. M., Montalto M., Cabrera J., Aerts C., Altavilla G., Belkacem K., Benatti S., Bergemann M., Börner A., Covone G., Deleuil M., Desidera S., Gizon L., Goupil M. J., Günther M., Heras A. M., Malavolta L., Mas-Hesse J. M., Nardiello D., Osborn H. P., Pagano I., Paproth C., Pollacco D., Prisinzano L., Ragazzoni R., Ramsay G., Rauer H., Udry S., Zingales T.   +32 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

WAYS AND METHODS TO OPTIMIZE THE SELECTION PROCESS OF PERSONNEL PARTICIPATING IN MULTINATIONAL OPERATIONS [PDF]

Romanian Intelligence Studies Review
Given Romania’s participation in multinational operations under the auspices of the United Nations and the leadership of international security organizations such as the North Atlantic Treaty Organization and the European Union, in this article we have ...
Alice-Claudița MANDEȘ
doaj  

Evaluating the Fellowship Selection Process: Opportunities for Improvement. [PDF]

Radiographics, 2023
Zaki-Metias KM, Bentley H, Hosseiny M, Vijan A.   +3 more
europepmc   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source