Results 131 to 140 of about 1,988,323 (265)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Practical guidance to advisors of residents on the fellowship selection process. [PDF]

J Community Hosp Intern Med Perspect, 2021
Alweis R, Salama A.
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Cancer Cell Fusion and Post-Hybrid Selection Process (PHSP). [PDF]

Cancers (Basel), 2021
Hass R, von der Ohe J, Dittmar T.
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Assessing the Reliability of the SICOT Orthopaedic Research Award Selection Process: An Analysis of the Score and the Scorers. [PDF]

Cureus
Beigh S, Cheung JP, Del Cruz R, Chen J, Jonayed S, Elbaseet H, Kenawey M, Sivananthan S, Almahri AK, Alshryda S.   +9 more
europepmc   +1 more source

Are the Player Selection Process and Performance Influenced by Relative Age Effect in Elite Women's Handball? [PDF]

J Hum Kinet, 2021
de la Rubia A, Lorenzo-Calvo J, Rivilla-García J, Marquina M.   +3 more
europepmc   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Patient-reported outcome measures for use in patients with alpha-1-antitrypsin deficiency: results of a systematic selection process. [PDF]

BMJ Open Respir Res
Müller K, Vogl L, Knüttel H, Greulich T, Lammert F, Strnad P, Vogelmeier CF, Wilkens M, Bals R, Koller M.   +9 more
europepmc   +1 more source

Understanding the Urology Program Directors Perspective on the Current Resident Selection Process: The Society of Academic Urologists National Survey of Urology Program Directors. [PDF]

J Surg Educ, 2023
Movassaghi M, Lemack GE, Badalato GM, Broderick G, Greene K, Ibeziako O, Mirza M, Murphy A, Thavaseelan S, Wolter C, Takacs E.   +10 more
europepmc   +1 more source