Results 171 to 180 of about 3,639,310 (295)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Data selection strategies for minimizing measurement time in materials characterization. [PDF]

Sci Rep
Liehr A, Dingel K, Kottke D, Degener S, Meier D, Sick B, Niendorf T.   +6 more
europepmc   +1 more source

The fan base for embryo selection strategies: enlightened or flummoxed. [PDF]

J Assist Reprod Genet, 2022
Albertini DF.
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Optimizing genomic selection strategies for carcass traits in commercial purebred ducks. [PDF]

Poult Sci
Cai W, Zhu L, Han C, Wang M, Yang Q, Liu Z, Zhou Z, Hu J, Hou S.   +8 more
europepmc   +1 more source

Oscillator Selection Strategies to Optimize a Physically Unclonable Function for IoT Systems Security. [PDF]

Sensors (Basel), 2023
Aparicio-Téllez R, Garcia-Bosque M, Díez-Señorans G, Celma S.   +3 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Efficacy of Various Sperm Selection Strategies in Obtaining Sperm with Improved DNA Integrity: A Prospective Study. [PDF]

Am J Mens Health
Dehghan Marvast L, Nabi A, Zakeri Y, Zandieh Z, Vahidi S, Shadpour P, Narimani N, Siri MA, Hosseini MA, Narouie B.   +9 more
europepmc   +1 more source

Development of selection strategies for genetic improvement in production traits of Mecheri sheep based on a Bayesian multi trait evaluation. [PDF]

PLoS One, 2023
Balasundaram B, Muralidharan J, Murali N, Cauveri D, Raja A, Okpeku M, Thiruvenkadan AK.   +6 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source