Results 81 to 90 of about 3,596,398 (274)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Simultaneous trait selection strategies applied to genome-wide selection for the identification of superior genotypes [PDF]
Pesquisa Agropecuária BrasileiraThe objective of this work was to evaluate the efficiency of direct and indirect selection in genome-wide selection (GWS) and to compare multivariate strategies applied to GWS via selection indices. Ten F2 populations with 800 individuals were simulated,
Lidiane Aparecida Silva +4 more
doaj +1 more source
, 2014 We consider a population living in a patchy environment that varies stochastically in space and time. The population is composed of two morphs (that is, individuals of the same species with different genotypes).
Evans, Steven N. +2 more
core +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Flaw Selection Strategies for Partial-Order Planning
, 1997 Several recent studies have compared the relative efficiency of alternative flaw selection strategies for partial-order causal link (POCL) planning. We review this literature, and present new experimental results that generalize the earlier work and ...
Joslin, D., Paolucci, M., Pollack, M. E.
core +3 more sources
Acknowledging the potential role of animal self-medication [PDF]
, 2002 This report was presented at the UK Organic Research 2002 Conference. Much research on animal health and welfare assumes that animals passively endure the pathogens, diet, and environmental conditions that come their way.
Engel, Cindy Reece
core
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Spike and slab variable selection: Frequentist and Bayesian strategies
, 2005 Variable selection in the linear regression model takes many apparent faces from both frequentist and Bayesian standpoints. In this paper we introduce a variable selection method referred to as a rescaled spike and slab model.
Ishwaran, Hemant, Rao, J. Sunil
core +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source