Results 81 to 90 of about 570,307 (263)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Selective exposure in different political information environments - How media fragmentation and polarization shape congruent news use. [PDF]
Steppat D, Castro Herrero L, Esser F.
europepmc +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Selective Exposure and Perceived Identification With Characters in Transnational Arabic Television
Given the transnational nature of the Arabic satellite television industry and the cultural differences among Arab regions, this experiment examined the role of social identity in Arab viewers’ media choices and perceived identification with characters.
Tamara Kharroub, Andrew J. Weaver
doaj
According to the selective exposure hypothesis, media consumption is determined by the ideological predispositions of individuals, who aim to confirm their opinions through media content.
Jaume Doménech-Beltrán
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Social media have a central role in the electoral success of populist parties. Online populist discourse may be persuasive because it oftentimes combines two powerful cues: (1) It emphasizes an all-encompassing divide between “good” ordinary people and “
Michael Hameleers
doaj
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
News consumption and trust are shifting across generations as the structures of media production and distribution are reshaped by technology. In the past decade, the rise of algorithmically curated feeds, influencer commentary, and platform-specific news
Iman Kassam, Jaigris Hodson
doaj +1 more source

