Results 121 to 130 of about 53,027 (281)

PUS7-dependent Ψ reshapes specific synaptic gene exons to facilitate fear extinction memory formation

Molecular Brain
RNA modifications serve as dynamic regulators of neural plasticity through their ability to fine-tune transcript stability and splicing. Pseudouridine (Ψ), an evolutionarily conserved RNA modification catalyzed by pseudouridine synthases, plays ...
Runming Liu, Yuhan Dong, Zhipeng Gao, Jichun Shi, Ziyue Xu, Junhui Liu, Gaomeng Luo, Shengda Ye, Feiyang Zhang, Hongyu Xu, Xiang Li, Sha Liu, Wei Wei   +12 more
doaj   +1 more source

Detection of Protein–Protein Interactions in Escherichia coli With Single Molecule Sensitivity

Advanced Science, EarlyView.
This article describes a regulatory circuit in Escherichia coli able to detect protein–protein interactions with exquisite sensitivity. The interaction between two hybrid proteins fused to Bordetella pertussis adenylate cyclase and its activator calmodulin triggers a potent cyclic AMP signaling cascade.
Marilyne Davi, Daniel Ladant
wiley   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Late Ordovician-Early Silurian selective extinction patterns in Laurentia and their relationship to climate change

, 2011
There is general agreement that the Late Ordovician mass extinction is causally related to climate change, but the precise mechanism of the relationship is not well established.
Fischer, W. W., Peters, S., Finnegan, S.
core  

Time‐Multiplexed Organic Electrochemical Transistor for Saliva‐Based Rapid Detection of Viral Proteins

Advanced Science, EarlyView.
A time‐multiplexed nanobody‐functionalized organic electrochemical transistor enables rapid and sensitive detection of three respiratory viral proteins from saliva. Sequentially addressed multi‐gate electrodes on a shared channel achieve around 1 fm detection within 15 min without sample preprocessing. Clinical validation demonstrates high specificity,
Tianrui Chang, Yuxiang Ren, Shofarul Wustoni, Atheer Alqatari, Adel Hama, Yazhou Wang, Long Chen, Jessica Parrado Agudelo, Luca Salvigni, Keying Guo, Ashraf Dada, Stefan T. Arold, Raik Grünberg, Sahika Inal   +13 more
wiley   +1 more source

Extinction at 7  

, 2006
The extinction laws at 7 ${\rm \mu}$m and 15 ${\rm \mu}$m are derived for more than 120 sightlines in the inner Galactic plane based on the ISOGAL survey data and the near-infrared data from DENIS and 2MASS. The tracers are the ISOGAL point sources with $
Simon, Guy, A. Omont, J. Gao, B. W. Jiang, Gao, J., Schuller, F., F. Schuller, G. Simon, Jiang, Biwei W., Omont, Alain   +9 more
core   +1 more source

Carboranyl‐Curcuminoids for the Neutron Capture‐Based Treatment of Amyloid Aggregates in Alzheimer's Disease

Advanced Science, EarlyView.
The 10B‐enriched monocarbonyl analog of curcumin (BMAC) 10B‐9 enables site‐specific Boron Neutron Capture Therapy (BNCT) on amyloid‐β (Aβ) fibrils. Neutron irradiation induces histidine oxidation and fibril destabilization, as revealed by 1H‐NMR and FESEM analyses.
Sebastiano Micocci, Stefano Parisotto, Diego Alberti, Alberto Lanfranco, Valeria Bitonto, Polyssena Renzi, Martina Salmi, Andrea Magnani, Federica Dal Bello, Katiuscia Pagano, Laura Ragona, Nicoletta Protti, Annamaria Deagostino, Simonetta Geninatti Crich   +13 more
wiley   +1 more source

Fluoxetine Facilitates Fear Extinction Through Amygdala Endocannabinoids.

, 2016
Pharmacologically elevating brain endocannabinoids (eCBs) share anxiolytic and fear extinction-facilitating properties with classical therapeutics, including the selective serotonin reuptake inhibitor, fluoxetine.
Ramikie, TS, Holmes, A, Flynn, S, Kaugars, K, Gunduz-Cinar, O, Cinar, R, Patel, S, Baldi, R, Kunos, G, Brockway, E   +9 more
core   +1 more source

ANKS1B in the Nucleus Accumbens Controls Escalated Cocaine Self‐Administration via Regulating CBP‐FoxO3 Complex

Advanced Science, EarlyView.
ANKS1B in the nucleus accumbens plays a critical role in the transition from controlled to escalated cocaine intake. Mechanistically, ANKS1B interacts with CBP to epigenetically suppress FoxO3 through H3K27 acetylation. The ANKS1B‐CBP‐FoxO3 signaling cascade presents a novel theraputic target for the treatment of cocaine addiction.
Liping Yang, Xiaoxuan Wu, Xuan Chen, Chao Peng, Zihang Li, Shumin Gao, Shiqiu Meng, Jing Dong, Dong Wu, Liying Lv, Ying Han, Yanxue Xue, Lin Lu, Jie Shi, Jianfeng Liu, Yan Sun   +15 more
wiley   +1 more source

Prefrontal inputs to the amygdala instruct fear extinction memory formation.

, 2015
Persistent anxiety after a psychological trauma is a hallmark of many anxiety disorders. However, the neural circuits mediating the extinction of traumatic fear memories remain incompletely understood.
Silverstein, S, Hartley, ND, Holmes, A, Pinard, CR, Colacicco, G, Patel, S, Whittle, N, Busch, E, Bukalo, O, Brehm, C, Singewald, N   +10 more
core   +1 more source