Results 51 to 60 of about 6,409,208 (237)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Fetal liver blood flow distribution: role in human developmental strategy to prioritize fat deposition versus brain development [PDF]

, 2012
Among primates, human neonates have the largest brains but also the highest proportion of body fat. If placental nutrient supply is limited, the fetus faces a dilemma: should resources be allocated to brain growth, or to fat deposition for use as a ...
Crozier, SR, Sarah R. Crozier, Sian M. Robinson, Guttorm Haugen (141243), Sarah R Crozier, Kiserud, T., Hanson, M.A., Inskip, H.M., Haugen Guttorm, Nicholas C. W. Harvey, Harvey Nicholas C. W., Crozier Sarah R., Haugen, G., Hazel M. Inskip, Robinson Sian M., Crozier, S.R., Inskip, HM, Mark A. Hanson (114427), Cyrus Cooper (141250), Godfrey, Keith M., Sian M Robinson, Mark A Hanson, Cyrus Cooper, Cooper Cyrus, Lucy Davies, Harvey, NC, Hazel M. Inskip (141248), Haugen, G, Guttorm Haugen, Harvey, N.C., Godfrey Keith M., Kiserud, T, Robinson, S.M., Mark A. Hanson, Keith M Godfrey, Nicholas C W Harvey, Hanson Mark A., Torvid Kiserud, Southampton Women's Survey Study Group, Cooper, Cyrus, Davies, L, Hanson, MA, Sarah R. Crozier (141254), Keith M. Godfrey, Inskip Hazel M., Godfrey, KM, Hazel M Inskip, Sian M. Robinson (141258), Kiserud Torvid, Keith M. Godfrey (141238), Cooper, C., Robinson, SM, Davies Lucy, Cooper, C, Torvid Kiserud (141246), Lucy Davies (141261), Davies, L., Nicholas C. W. Harvey (141252)   +57 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Sudden Onset of Severe Pulmonary Hypertension in a Preterm Infant: A Case Report on the Role of Maternal Use of Serotonin Re-Uptake Inhibitors During Pregnancy and Concurrent Risk Factors

Frontiers in Pediatrics, 2022
Persistent pulmonary hypertension of the newborn (PPHN) is a severe condition caused by failed circulatory adaptation at birth. Pulmonary hypertension is most common in full-term infants and rare in preterms, although it is increasingly diagnosed also in
Isabella Buffoni, Silvia Buratti, Marisa F. Mallamaci, Stefano Pezzato, Elisabetta Lampugnani, Francesca Buffelli, Ezio Fulcheri, Ezio Fulcheri, Andrea Moscatelli   +8 more
doaj   +1 more source

The Role of Genes and Environment on Fetal Growth [PDF]

, 2014
Fetal growth is influenced by the in utero environment and genetic factors inherited from both parents. Poor fetal growth leading to low birth weight is associated with insulin resistance and type-2 diabetes in later life.
Hillman, SL
core  

Early onset fetal growth restriction [PDF]

, 2016
Fetal growth restriction remains a challenging entity with significant variations in clinical practice around the world. The different etiopathogenesis of early and late fetal growth restriction with their distinct progression of fetal severity and ...
Nawathe, A, Lees, C
core   +1 more source

The diagnosis and management of suspected fetal growth restriction: an evidence-based approach

, 2022
This article reviews the literature about the diagnosis, antepartum surveillance, and timing of delivery of fetuses suspected to be small for gestational age/growth restricted.
Romero, R, Prefumo, F, Maulik, D, Frusca, T, Dall'asta, A, Campbell, S, Baschat, A, Galan, H, Da Silva Costa, Fabricio, Hobbins, J, Stampalija, T, DeVore, G, Visser, GHA, Bilardo, CM, et al., Lees, C   +15 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Detailed statistical analysis plan for the Dutch STRIDER (Sildenafil TheRapy In Dismal prognosis Early-onset fetal growth Restriction) randomised clinical trial on sildenafil versus placebo for pregnant women with severe early onset fetal growth restriction

Trials, 2019
Objective The objective of the Dutch Sildenafil therapy in dismal prognosis early onset fetal growth restriction (STRIDER) randomised clinical trial is to assess the beneficial and harmful effects of sildenafil versus placebo on fetal and neonatal ...
Anouk Pels, Janus C. Jakobsen, Wessel Ganzevoort, Christiana A. Naaktgeboren, Wes Onland, Aleid G. van Wassenaer-Leemhuis, Christian Gluud   +6 more
doaj   +1 more source