Results 41 to 50 of about 6,199,037 (239)

Expectant Management of Monochorionic-Triamniotic Triplets Complicated by Selective In Utero Growth Restriction: Report of 2 Cases

Case Reports in Obstetrics and Gynecology, 2020
The optimal management of monochorionic-triamniotic (MCTA) triplet pregnancies is not clearly established, and there is no literature to guide management of MCTA complicated with selective intrauterine growth restriction (sIUGR).
Laurence Carmant, Sandrine Wavrant, Elisabeth Codsi   +2 more
doaj   +1 more source

Risk factors and analysis of retinopathy of prematurity in monochorionic diamniotic twins

Journal of Perinatal Medicine
To investigate the impact of intrauterine pathologies, including twin-to-twin transfusion syndrome (TTTS) and selective intrauterine growth restriction (sIUGR), on the development of retinopathy of prematurity (ROP) in monochorionic diamniotic (MCDA ...
Zhao Yixue, Gao Bo, Li Huixian, Du Yue, Wu Yucan, Chen Guijun, Chen Menger, Li Mingqian, Wang Ping   +8 more
doaj   +1 more source

Preliminary report of altered insulin secretion pattern in monochorionic twin pregnancies complicated with selective intrauterine growth restriction

Taiwanese Journal of Obstetrics & Gynecology, 2017
Objective: Fetuses with intrauterine growth restriction (IUGR) have adaptive hormonal changes including changes in insulin, which may increase their future risks for developing diabetes mellitus.
Yao-Lung Chang, Tzu-Hao Wang, Seham M. Abufraijeh, Shuenn-Dyh Chang, An-Shine Chao, Peter C.C. Hsieh   +5 more
doaj   +1 more source

Comparison of the ratio of placental territory discordance to birthweight discordance in placentas of monochorionic diamniotic twins

Science Progress, 2021
The ratio of placental territory discordance to birthweight discordance was calculated in monochorionic diamniotic twin placentas. We then determined whether the ratio: (1) correlated with the overall diameter of the placental superficial vascular ...
Wang Xueju, Li Luyao, Yuan Pengbo, Shi Huifeng, Zhao Yangyu, Wei Yuan   +5 more
doaj   +1 more source

Association between intrauterine growth restriction and patent ductus arteriosus: Use of a dichorionic twin pregnancy model

Taiwanese Journal of Obstetrics & Gynecology, 2021
Objective: To evaluate the association between intrauterine growth restriction (IUGR) and the incidence of fetuses with patent ductus arteriosus (PDA) and Hemodynamically significant PDA (Hs-PDA) in dichorionic twins (DC) with selective IUGR.
Chung-Yuan Yang, Michael FW. Hoong, Chung-Sing Li, Wen-Fang Li, Shu-Han You, Yen-Chang Lee, Hsiu-Huei Peng, Ho-Yen Chueh, An-Shine Chao, Po-Jen Cheng, Shuenn-Dyh Chang, Reyin Lien, Yao-Lung Chang   +12 more
doaj   +1 more source

NSUN2‐Mediated m5C Modification of TGFB1 in Trophoblasts Remodels Macrophage Function to Prevent URSA

Advanced Science, EarlyView.
NSUN2 and m5C decline in URSA villous tissues. Trophoblast Nsun2 ablation disrupts macrophage‐mediated maternal‐fetal tolerance and triggers embryo resorption. Mechanistically, NSUN2‐YBX1 axis stabilizes m5C‐modified TGFB1 mRNA to maintain TGF‐β1 secretion and M2 polarization, and restoring this signaling rescues maternal‐fetal immune tolerance to ...
Xiaoxiao Zhu, Xinkui Liu, Xiaoyan Yu, Qiaoqiao Han, Feifei Shi, Weiwei Song, Lu Liu, Chu Chu, Chenyang Shen, Zhen Zhang, Xia Li   +10 more
wiley   +1 more source

Heterozygous Variants in LRP1 Cause a Neurodevelopmental Disorder With Congenital Heart Defects

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT LRP1 encodes the low‐density lipoprotein (LDL) receptor‐related protein 1 (LRP1), a transmembrane protein involved in endocytosis and activation of multiple signaling pathways. LRP1 variants have been implicated in the pathogenesis of congenital heart defects (CHD), Alzheimer's disease, and neurodevelopmental disorders (NDD).
Alyssa L. Rippert, Gudny Anna Arnadottir, Laura Bedinger, Nicola Brunetti‐Pierri, Jennifer Cech, Xin Chen, Yanmin Chen, Erika Chick, Sarah Dyack, Madeleine Franchi, Tanja Frey, David Genevieve, Ian Glass, Jorge Granadillo, Kelly A. Keener, Sara B. MacKay, Paige McDunnah, Vinod K. Misra, Kristin G. Monaghan, Sureni V. Mullegama, Cristina Peduto, Leia Peterman‐Prather, Anita Rauch, Cherith Somerville, Kari Stefansson, Katharina Steindl, Patrick Sulem, Telma Sulem, Pamela Trapane, Roberta Zeuli, Samuel Zinner, Kosuke Izumi   +31 more
wiley   +1 more source

Development of Non-Viral, Trophoblast-Specific Gene Delivery for Placental Therapy. [PDF]

PLoS ONE, 2015
Low birth weight is associated with both short term problems and the fetal programming of adult onset diseases, including an increased risk of obesity, diabetes and cardiovascular disease.
Noura Abd Ellah, Leeanne Taylor, Weston Troja, Kathryn Owens, Neil Ayres, Giovanni Pauletti, Helen Jones   +6 more
doaj   +1 more source

A Rare Form of Microcephalic Primordial Dwarfism due to NSMCE2 Deficiency (Seckel Syndrome Type 10): A Report of Macular Involvement

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Biallelic variants in NSMCE2 (MMS21), which encodes the SUMO E3 ligase subunit of the SMC5/6 chromatin‐maintenance complex, have recently been implicated in microcephalic primordial dwarfism (MPD), corresponding to Seckel syndrome type 10 (OMIM #617246).
Cristina Peduto, Céline Huber, Clément Paya, Isabelle Audo, Nathalie Boddaert, Valérie Cormier‐Daire   +5 more
wiley   +1 more source

Therapy for Myhre Syndrome: Goals, Misconceptions, and Current Agents

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre Syndrome (MYHRS, MIM #139210) is a rare, multisystem connective tissue disorder caused by recurrent heterozygous gain‐of‐function pathogenic variants in the SMAD4 gene, a key player in TGF‐β signaling and a regulator of extracellular matrix homeostasis.
Alessandro De Falco, Alfonso Manuel D'Alessio, Nicola Brunetti‐Pierri   +2 more
wiley   +1 more source