Results 191 to 200 of about 350,044 (262)

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Dental prophylactic interventions are associated with lower decompensation-related hospitalizations over 2 years in cirrhosis. [PDF]

JHEP Rep
Bajaj JS, Silvey S, Aljabi A, Golob Deeb J, Patel N.   +4 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Stage-dependent endoplasmic reticulum homeostasis in osteogenic differentiation. [PDF]

Front Cell Dev Biol
Wang J, Li X, Wang X, Wang L, Zhang Y, Dong X, Lu X, Wang S.   +7 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Counting the CHIPs: The High-Stakes Role of Clonal Hematopoiesis in Multiple Myeloma. [PDF]

Biomedicines
Szalay M, Seguel Strange I, Banwell K, Campana S, Dass A, Hej-Ali S, Mohamed H, Khan S.   +7 more
europepmc   +1 more source

Stage- and compartment-specific remodeling of autophagy and selective mitophagy in glaucoma: from aqueous outflow dysfunction to retinal ganglion cell neurodegeneration. [PDF]

Front Cell Dev Biol
Zhou P, Deng Y, Zhou Y, Lu J, Peng Q, Yang Y.   +5 more
europepmc   +1 more source

Advances in the Management of Pediatric Inflammatory Bowel Disease: From Biologics to Small Molecules. [PDF]

Pharmaceuticals (Basel)
Mucci B, Palazzolo E, Ruberti F, Ientile L, Natale M, Esposito S.   +5 more
europepmc   +1 more source

Liver sinusoidal endothelial cell fenestrations in metabolic liver disease: from molecular mechanisms to therapeutic perspectives. [PDF]

Cell Commun Signal
Al-Mughalles AS, Ma J, Ma H, Zhang C, Xiao H, Ma X, Zhang Q, Jia C, Han H, Ding BS, Zhang S.   +10 more
europepmc   +1 more source