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Bioengineered Lymphatic Vessels in Synthetic Matrices to Study Breast Cancer Cell Functions
Advanced Healthcare Materials, EarlyView.Lymphatic vessels are involved in cancer metastasis. To study the interplay between metastasizing cancer cells and lymphatic vessels under highly reproducible conditions, advanced in vitro models are required. In this work, 3D lymphatic networks are formed in biomimetic hydrogels and their interactions with invasive and non‐invasive cancer cell‐lines ...
Rodi Odabasi +7 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.A 3D biomimetic OS model was developed by bioprinting an OS‐cell‐derived dECM‐enriched bioink with OS spheroids incorporated. The model showed upregulation of known OS prognostic markers and increased resistance to doxorubicin, compared to 2D cultures and scaffold‐free spheroids, making this a more clinically relevant platform for drug discovery ...
Margarida F. Domingues +6 more
wiley +1 more source
Correction for Khan et al., Global selective sweep of a highly inbred genome of the cattle parasite Neospora caninum. [PDF]
Proc Natl Acad Sci U S A, 2019 europepmc +1 more source
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Approximating selective sweeps
Theoretical Population Biology, 2004The fixation of advantageous mutations in a population has the effect of reducing variation in the DNA sequence near that mutation. Kaplan et al. (1989) used a three-phase simulation model to study the effect of selective sweeps on genealogies. However, most subsequent work has simplified their approach by assuming that the number of individuals with ...
Durrett, Richard, Schweinsberg, Jason
openaire +3 more sources
Landmarks in the history of selective sweeps
Animal Genetics, 2023AbstractHalf a century ago, a seminal article on the hitchhiking effect by Smith and Haigh inaugurated the concept of the selection signature. Selective sweeps are characterised by the rapid spread of an advantageous genetic variant through a population and hence play an important role in shaping evolution and research on genetic diversity. The process
Manjit Panigrahi +9 more
openaire +2 more sources
Software: Practice and Experience, 2005
Traditional mark and sweep garbage collectors use time proportional to the heap size when sweeping memory, since all objects in the heap, dead or alive, must be traversed. Here we introduce a sweeping algorithm which traverses only the live objects. Since this sweeping algorithm is slower when the heap occupancy is high, we also discuss how to avoid ...
Yoo C. Chung +3 more
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Traditional mark and sweep garbage collectors use time proportional to the heap size when sweeping memory, since all objects in the heap, dead or alive, must be traversed. Here we introduce a sweeping algorithm which traverses only the live objects. Since this sweeping algorithm is slower when the heap occupancy is high, we also discuss how to avoid ...
Yoo C. Chung +3 more
openaire +1 more source
Hitchhiking and Selective Sweeps
2018When a favorable allele increases in frequency, it alters the coalescent structure (the pattern of times back to a common ancestor) at linked sites relative to that under drift. This creates patterns of sequence polymorphism than can be used to potentially detect ongoing, or very recent, selection.
Bruce Walsh, Michael Lynch
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Selective sweeps in Cryptocercus woodroach antifungal proteins
Genetica, 2016We identified the antifungal gene termicin in three species of Cryptocercus woodroaches. Cryptocercus represents the closest living cockroach lineage of termites, which suggests that the antifungal role of termicin evolved prior to the divergence of termites from other cockroaches.
Joseph F, Velenovsky +2 more
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Identification of selective sweeps in bacteria
2023AbstractSelective sweeps occur when a beneficial mutation spreads rapidly throughout the population due to natural selection. Searching for selective sweeps has proved to be one of the most fruitful ways to detect the footprints selection leaves on the genome.
Oren Avram +4 more
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Sweeping range control in a self-sweeping laser with selective mirrors
Advanced Sensor Systems and Applications VIII, 2018The laser wavelength in self-sweeping laser is linearly changing in time from start to stop wavelength without use of optical elements and electrical drivers for frequency tuning. Absolute difference between the start and stop wavelength values (sweeping span) characterizing the sweeping process is one of the key characteristics of any tunable source ...
Sergey Kablukov +3 more
openaire +1 more source