Results 241 to 250 of about 56,592 (279)

Development of a Synthetic 3D Platform for Compartmentalized Kidney In Vitro Disease Modeling

Advanced Healthcare Materials, EarlyView.
A fully synthetic, compartmentalized 3D kidney disease model is introduced. The kidney model combines a PEG‐based hydrogel matrix with anisotropic, enzymatically degradable rod‐shaped microgels to spatially arrange a triple co‐culture of key renal epithelial, endothelial, and fibroblast cells.
Ninon Möhl, Daphne Bouwens, Johanna Abele, Aline Hans, Tanja Topic, Daniel Günther, Jitske Jansen, Rafael Kramann, Laura De Laporte   +8 more
wiley   +1 more source

Bioengineered Lymphatic Vessels in Synthetic Matrices to Study Breast Cancer Cell Functions

Advanced Healthcare Materials, EarlyView.
Lymphatic vessels are involved in cancer metastasis. To study the interplay between metastasizing cancer cells and lymphatic vessels under highly reproducible conditions, advanced in vitro models are required. In this work, 3D lymphatic networks are formed in biomimetic hydrogels and their interactions with invasive and non‐invasive cancer cell‐lines ...
Rodi Odabasi, Lisa A. Krattiger, Magdalini Kanari, Mira A. Jacobs, Lukas O. Moser, Mark W. Tibbitt, Cornelia Halin, Martin Ehrbar   +7 more
wiley   +1 more source

A 3D Bioprinted Spheroid‐Laden dECM‐Enriched Osteosarcoma Model for Enhanced Drug Testing and Therapeutic Discovery

Advanced Healthcare Materials, EarlyView.
A 3D biomimetic OS model was developed by bioprinting an OS‐cell‐derived dECM‐enriched bioink with OS spheroids incorporated. The model showed upregulation of known OS prognostic markers and increased resistance to doxorubicin, compared to 2D cultures and scaffold‐free spheroids, making this a more clinically relevant platform for drug discovery ...
Margarida F. Domingues, Maria Catarina Carreira, Mafalda S. Santos, Daniela Pacheco, Frederico Castelo Ferreira, Paola Sanjuan‐Alberte, João Carlos Silva   +6 more
wiley   +1 more source

Copy number variants underlie the major selective sweeps in insecticide resistance genes inAnopheles arabiensisfrom Tanzania

Lucas ER, Nagi SC, Kabula B, Batengana B, Kisinza W, Egyir-Yawson A, Essandoh J, Dadzie S, Chabi J, Van’t Hof AE, Rippon EJ, Pipini D, Harding NJ, Dyer NA, Clarkson CS, Miles A, Weetman D, Donnelly MJ.   +17 more
europepmc   +1 more source

Genome-wide selective sweeps and gene-specific sweeps in natural bacterial populations [PDF]

ISME Journal, 2016
Abstract Multiple models describe the formation and evolution of distinct microbial phylogenetic groups. These evolutionary models make different predictions regarding how adaptive alleles spread through populations and how genetic diversity is maintained.
Matthew Bendall, Sarah L R Stevens, Julien Tremblay   +2 more
exaly   +6 more sources

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Approximating selective sweeps

Theoretical Population Biology, 2004
The fixation of advantageous mutations in a population has the effect of reducing variation in the DNA sequence near that mutation. Kaplan et al. (1989) used a three-phase simulation model to study the effect of selective sweeps on genealogies. However, most subsequent work has simplified their approach by assuming that the number of individuals with ...
Durrett, Richard, Schweinsberg, Jason
openaire   +3 more sources

Landmarks in the history of selective sweeps

Animal Genetics, 2023
AbstractHalf a century ago, a seminal article on the hitchhiking effect by Smith and Haigh inaugurated the concept of the selection signature. Selective sweeps are characterised by the rapid spread of an advantageous genetic variant through a population and hence play an important role in shaping evolution and research on genetic diversity. The process
Manjit Panigrahi, Divya Rajawat, Sonali Sonejita Nayak, Kanika Ghildiyal, Anurodh Sharma, Karan Jain, Chuzhao Lei, Bharat Bhushan, Bishnu Prasad Mishra, Triveni Dutt   +9 more
openaire   +2 more sources

Selective sweeping

Software: Practice and Experience, 2005
Traditional mark and sweep garbage collectors use time proportional to the heap size when sweeping memory, since all objects in the heap, dead or alive, must be traversed. Here we introduce a sweeping algorithm which traverses only the live objects. Since this sweeping algorithm is slower when the heap occupancy is high, we also discuss how to avoid ...
Yoo C. Chung, Soo-Mook Moon, Kemal Ebcio?lu, Dan Sahlin   +3 more
openaire   +1 more source

Hitchhiking and Selective Sweeps

2018
When a favorable allele increases in frequency, it alters the coalescent structure (the pattern of times back to a common ancestor) at linked sites relative to that under drift. This creates patterns of sequence polymorphism than can be used to potentially detect ongoing, or very recent, selection.
Bruce Walsh, Michael Lynch
openaire   +1 more source

Linkage Disequilibrium as a Signature of Selective Sweeps [PDF]

Genetics, 2004
Abstract The hitchhiking effect of a beneficial mutation, or a selective sweep, generates a unique distribution of allele frequencies and spatial distribution of polymorphic sites. A composite-likelihood test was previously designed to detect these signatures of a selective sweep, solely on the basis of the spatial distribution and ...
Yuseob Kim, Rasmus Nielsen
exaly   +3 more sources