Results 101 to 110 of about 6,326,915 (384)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Energy transfer-mediated multiphoton synergistic excitation for selective C(sp 3)–H functionalization with coordination polymer

Nature Communications
Activation and selective oxidation of inert C(sp 3)–H bonds remain one of the most challenging tasks in current synthetic chemistry due to the inherent inertness of C(sp 3)–H bonds.
Zhonghe Wang, Yang Tang, Songtao Liu, Liang Zhao, Huaqing Li, Cheng He, Chunying Duan   +6 more
doaj   +1 more source

Bio-Inspired Fine-Tuning for Selective Transfer Learning in Image Classification

IEEE Access
Deep learning has significantly advanced image analysis across diverse domains but often depends on large, annotated datasets for success. Transfer learning addresses this challenge by utilizing pre-trained models to tackle new tasks with limited labeled
Ana Davila, Jacinto Colan, Yasuhisa Hasegawa   +2 more
doaj   +1 more source

A transwell assay that excludes exosomes for assessment of tunneling nanotube-mediated intercellular communication

Cell Communication and Signaling, 2017
Background Tunneling nanotubes (TNTs) are naturally-occurring filamentous actin-based membranous extensions that form across a wide spectrum of mammalian cell types to facilitate long-range intercellular communication.
Venugopal Thayanithy, Patrick O’Hare, Phillip Wong, Xianda Zhao, Clifford J. Steer, Subbaya Subramanian, Emil Lou   +6 more
doaj   +1 more source

Transfer learning approach for financial applications [PDF]

, 2015
Artificial neural networks learn how to solve new problems through a computationally intense and time consuming process. One way to reduce the amount of time required is to inject preexisting knowledge into the network.
Magoulas, George D., Stamate, Cosmin, Thomas, Michael S. C.   +2 more
core  

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Tuning light-driven oxidation of styrene inside water-soluble nanocages

Nature Communications
Selective functionalization of innate sp2 C-H bonds under ambient conditions is a grand synthetic challenge in organic chemistry. Here we combine host-guest charge transfer-based photoredox chemistry with supramolecular nano-confinement to achieve ...
Souvik Ghosal, Ankita Das, Debojyoti Roy, Jyotishman Dasgupta   +3 more
doaj   +1 more source

Overcoming Selectivity Issues in Reversible Catalysis – A Transfer Hydrocyanation Exhibiting High Kinetic Control [PDF]

, 2020
Benjamin N. Bhawal, Julia C. Reisenbauer, Christian Ehinger, Bill Morandi   +3 more
openalex   +1 more source