Results 291 to 300 of about 6,326,915 (384)

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Mediator-Enabled Co-Catalyzed <i>Z</i>‑Selective Semihydrogenation via Hydride-Free Multisite Proton-Coupled Electron Transfer. [PDF]

ACS Catal
Parnitzke B, Lalisse R, Gerhardt E, Maity T, Liu Y, Xuan Z, Gutierrez O, Derosa J.   +7 more
europepmc   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Iron photocatalysis towards site-selective C(sp³)-H alkylation of glycines and peptides. [PDF]

Chem Sci
Panda SP, Prasad MS, Meher P, Reiser O, Murarka S.   +4 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Advances in Coumarin Fluorescent Probes for Medical Diagnostics: A Review of Recent Developments. [PDF]

Biosensors (Basel)
Szwaczko K, Kulkowska A, Matwijczuk A.
europepmc   +1 more source

Iron-Catalyzed Stereoselective Nitrogen Atom Transfer for 1,2-<i>cis</i>-Selective Glycosylation. [PDF]

Synlett
Xu H, Zhang D, Jiang Z, Yin L, Clark SI, Wang P, Lamar JD, Cohen AM.   +7 more
europepmc   +1 more source

Clinical and Environmental Plasmids: Antibiotic Resistance, Virulence, Mobility, and ESKAPEE Pathogens. [PDF]

Antibiotics (Basel)
Domingues CPF, Rebelo JS, Dionisio F, Nogueira T.   +3 more
europepmc   +1 more source

Plasmonic Hot-Carrier Redox Enables Proton-Coupled Electron Transfer at C─H Bonds. [PDF]

Angew Chem Int Ed Engl
Latchev DV, Andreis A, Heeg JM, Sá J.
europepmc   +1 more source

Direct Aziridine Synthesis from Amines and Styrene Derivatives via a Base-Promoted Oxidative Cascade Reaction. [PDF]

J Am Chem Soc
Vásquez Tapia Vera C, Hughes WB, Klaus DR, Paton RS, Bandar JS.   +4 more
europepmc   +1 more source