Results 41 to 50 of about 1,416,783 (246)
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Huli yanjiu, 2021 ObjectiveTo investigate the status quo of exercise intention in patients with chronic kidney disease，and to explore its influencing factors.MethodsA questionaire survey，involving 236 non⁃dialysis patients with chronic kidney disease in a tertiary ...
XUE Leyi +4 more
doaj
Self-Efficacy of First-Generation College Students and the Relationship to Academic Performance and College Adjustment [PDF]
, 2007 The authors examined whether self-efficacy mediated the relationship between generational status and 2 academic outcome indicators of 192 college students. A mediation effect was not found with either academic performance or college adjustment.
Nichols, Laura, Ramos-Sánchez, Lucila
core +1 more source
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Huli yanjiu, 2020 ObjectiveTo explore the correlation between self⁃efficacy，disease activity index and quality of life in patients with inflammatory bowel disease.MethodsA total of 173 patients with inflammatory bowel disease，who were admitted into gastroenterology ...
GUAN Yuxia +5 more
doaj
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick +19 more
wiley +1 more source
Motivation and Organizational Culture on Performance with Self-efficacy Mediation [PDF]
, 2016 The study aims to determine firstly the direct effect of motivation on performance,secondly the indirect effect of motivation on performance mediated by self efficacy, thirdlythe direct influence of organizational culture on the performance, and lastly ...
Heriningsih, S. (Sucahyo) +1 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano +11 more
wiley +1 more source
School Counseling Site Supervisor Training: An Exploratory Study
, 2011 This study explored the supervision training needs of site supervisors of master’s program school counseling interns via the construct of selfefficacy. Using the Site Supervisor Self-Efficacy Survey developed for this study, the authors surveyed school ...
DeKruyf, Lorraine +1 more
core +1 more source