Results 141 to 150 of about 7,366,469 (392)

Oxycodone self-administration and withdrawal behaviors in male and female Wistar rats

Psychopharmacology, 2020
A. Kimbrough, Jenni Kononoff, S. Simpson, M. Kallupi, Sharona Sedighim, Kenia Palomino, Dana Conlisk, J. Momper, G. de Guglielmo, O. George   +9 more
semanticscholar   +1 more source

Reliability, Satisfaction and Effectiveness of Benralizumab Home Self-Administration in Patients with Severe Eosinophilic Asthma in Real-World Practice: The Auto-Benra Study

Journal of Asthma and Allergy, 2022
Ismael García-Moguel,1,2 Ana Rosado,3 Aída Gómez-Cardeñosa,4,5 Mar Gandolfo-Cano,6,7 Teresa Robledo Echarren,8 Maria del Mar Moro Moro,9 Mª del Mar Reaño Martos,10 Rafael Pineda-Pineda,11 Marcela Valverde-Monge,4,5 Cristina Martin-Arriscado Arroba,12 ...
García-Moguel I, Rosado A, Gómez-Cardeñosa A, Gandolfo-Cano M, Robledo Echarren T, Moro Moro MDM, Reaño Martos MDM, Pineda-Pineda R, Valverde-Monge M, Martin-Arriscado Arroba C, Domínguez-Ortega J   +10 more
doaj  

The Novel CYP2A6 Inhibitor, DLCI-1, Decreases Nicotine Self-Administration in Mice. [PDF]

, 2020
During tobacco and e-cigarette use, nicotine is mainly metabolized in the human liver by cytochrome P450 2A6 (CYP2A6). Given that a slower CYP2A6 metabolism has been associated with less vulnerability to develop nicotine dependence, the current studies ...
Chen, Yen-Chu, Denton, Travis T, Fowler, Christie D, Fowler, James P, Lazarus, Philip, Sherafat, Yasmine, Staben, Andres, Wang, Jing, Watson, Christy JW   +8 more
core  

Patatin‐domain‐containing (phospho)lipases under control: Mammalian co‐regulators and pathogenic activation mechanisms

FEBS Open Bio, EarlyView.
Patatin domain‐containing (phospho)lipases are lipid‐hydrolyzing enzymes central to metabolism, membrane remodeling, and signaling. Their activity relies on precise co‐activation mechanisms involving protein–protein interactions and conformational rearrangements.
Noopur Dubey, Lina Riegler‐Berket, Monika Oberer   +2 more
wiley   +1 more source

Editorial: Sex differences in the neurobiology of drug relapse vulnerability

Frontiers in Behavioral Neuroscience, 2023
Daniel F. Manvich, Jessica A. Loweth, Wendy J. Lynch, Jayme R. McReynolds   +3 more
doaj   +1 more source

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

Aging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath, Mathigatta Shivarudraiah S, Rajath Govind, Kaushik M R   +3 more
wiley   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Formulation and Evaluation of Self-Emulsifying Drug Delivery Systems of Larotaxel for Oral Administration [PDF]

, 2023
Wang Ming-li, Jing Shan, Yaping Tian, Jingxin Gou, H. Haibing, Wang Yanjiao, Zifei Yu, Tao Xing   +7 more
openalex   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

MT-7716, a potent NOP receptor agonist, preferentially reduces ethanol seeking and reinforcement in post-dependent rats

, 2015
Dysregulation of the nociceptin (N/OFQ) system has been implicated in alcohol abuse and alcoholism, and growing evidence suggests that targeting this system may be beneficial for treating alcoholism.
Aujla, Ayanwuyi, Braconi, Bunzow, Ciccocioppo, Ciccocioppo, Ciccocioppo, Ciccocioppo, Ciccocioppo, Ciccocioppo, Cruz, Eckardt, Economidou, Economidou, Erb, Everitt, Funk, Gozzi, Hansson, Hansson, Kallupi, Le, Liu, Macey, Martin-Fardon, Martin-Fardon, Mollereau, Neal, Roberto, Roberts, Rodd, Silberman, Sommer, Teshima, Valdez, Weiss, Wise, Zhao, Zorrilla   +38 more
core   +1 more source