Results 61 to 70 of about 240,671 (273)

Revealing mammalian evolutionary relationships by comparative analysis of gene clusters [PDF]

open access: yes, 2012
Many software tools for comparative analysis of genomic sequence data have been released in recent decades. Despite this, it remains challenging to determine evolutionary relationships in gene clusters due to their complex histories involving ...
Abi-Rached   +89 more
core   +2 more sources

Characterizing Parental Concerns About Lasting Impacts of Treatment in Children With B‐Acute Lymphoblastic Leukemia

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background B‐acute lymphoblastic leukemia (B‐ALL) is the most common pediatric cancer, and while most children in high‐resource settings are cured, therapy carries risks for long‐term toxicities. Understanding parents’ concerns about these late effects is essential to guide anticipatory support and inform evolving therapeutic approaches ...
Kellee N. Parker   +7 more
wiley   +1 more source

Reinforced Mnemonic Reader for Machine Reading Comprehension

open access: yes, 2018
In this paper, we introduce the Reinforced Mnemonic Reader for machine reading comprehension tasks, which enhances previous attentive readers in two aspects. First, a reattention mechanism is proposed to refine current attentions by directly accessing to
Hu, Minghao   +5 more
core   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

Redundant Constraints in Crane Disc Brake Mechanism: Effect and Disposal Perspectives

open access: yesCommunications
In this paper is considered a promising design of the braking disk mechanism of a construction crane. The analysis of the kinematics of the brake pad drive has shown that due to redundant links in the brake pad drive mechanism the latter are not able to ...
Vladyslav Protsenko   +6 more
doaj   +1 more source

Self-Alignment of Gold Nanorods Within Cellulose Based Liquid Crystals [PDF]

open access: yes, 2012
In this work, I use cellulose nanocrystals and demonstrate the long-range bulk dispersion and self-alignment of anisotropic metal nanoparticles at well-de ned orientation with respect to the far- eld liquid crystal director.
Campbell, Michael
core   +2 more sources

Record Maximum Oscillation Frequency in C-face Epitaxial Graphene Transistors

open access: yes, 2013
The maximum oscillation frequency (fmax) quantifies the practical upper bound for useful circuit operation. We report here an fmax of 70 GHz in transistors using epitaxial graphene grown on the C-face of SiC.
Badmaev A.   +42 more
core   +3 more sources

Optimization of graphene-based materials outperforming host epoxy matrices [PDF]

open access: yes, 2015
The degree of graphite exfoliation and edge-carboxylated layers can be controlled and balanced to design lightweight materials characterized by both low electrical percolation thresholds (EPT) and improved mechanical properties.
De Vivo, B.   +9 more
core   +3 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

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