Results 121 to 130 of about 220,803 (287)

Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling

Advanced Science, EarlyView.
Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu, Zhi‐Bin Hu, Ling Hu, Yu‐Bing Wang, Qiong Zhang, Ning‐Ning Song, Xi‐Yue Liu, Jia‐Yin Chen, Hong‐Wen Zhu, Bing‐Yao Zhou, Yun‐Chao Tao, Li Zhao, Ze‐Xuan Li, Yi‐Wei Li, Jia‐Qi Chen, Si‐Xin Tu, Cong‐Cong Qi, Sai‐Dan Ding, Gang Peng, Lin Xu, Yu‐Qiang Ding   +20 more
wiley   +1 more source

Neurotic Factors of Self-Attitude Disorders in Adolescents [PDF]

Advances in Social Science, Education and Humanities Research, 2021
Olena Tyshchenko, Ivan Okhrimenko, Denys Aleksandrov   +2 more
openaire   +1 more source

FOCUS: A Four‐In‐One Consolidated Unison Strain Sensor with Enhanced Sensitivity

Advanced Science, EarlyView.
Through a folding transformation that stacks four printed liquid metal sensors into a unified 3D orthogonal construct, FOCUS harnesses complementary bidirectional resistance responses within a Wheatstone bridge. This architecture yields fivefold sensitivity enhancement and 25 µm resolution, overcoming LM sensors’ micro‐strain limitations and enabling ...
Zimeng Wang, Ruiran Li, Bowen Yang, Zhuofei Peng, Muyang Jing, Yu Gu, Lixue Tang   +6 more
wiley   +1 more source

The model of empirical research of communicative practices of self-consciousness development as a factor of civic and national self-identification of youth [PDF]

Вихідними теоретико-методологічними засадами емпіричного досліджен¬ня комунікативних практик розвитку самосвідомості особистості як чинника громадянської та національної самоідентифікації молоді визначено такі твердження: комунікація є смисловим ...
Скнар, Оксана Миколаївна
core  

Projective drawing as the research instrument of youth political practices [PDF]

, 2015
Окреслено потенціал використання проективної методики «психологічний малюнок» для дослідження особливостей громадянських (політичних) практик молоді. Визначено переваги й обмеження застосування проективних методик. Розкрито сутність проекції як основного
Скнар, Оксана Миколаївна
core  

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

Advanced Science, EarlyView.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su, Guang Li, Yudong Guan, Qi Tian, Youzhi Qi, Yanqiu Zhang, Wenqian Wei, Xinxin Duan, Jiaxin Rui, Hongyan Zhu, Zengping Lin, Changchuan Xie, Zheni Xu, Yaying Wu, Xin Peng, Zhenjie Wang, Kun Chen, Xiaoyan Xin, Bing Zhang   +18 more
wiley   +1 more source

The “Diagnosis of Personal and Professional Feasibility” Methodology: Structure and Psychometric Justification

Bulletin of Kharkiv National University of Internal Affairs
The article presents the results of the development and psychometric testing of the author’s methodology “Diagnostics of personal and professional feasibility”, which is a tool for comprehensive assessment of personal and professional components of ...
Ya. S. Ponomarenko
doaj   +1 more source

Neuromorphic Motor Control with Electrolyte‐Gated Organic Synaptic Transistors

Advanced Electronic Materials, EarlyView.
Electrolyte‐gated organic synaptic transistor (EGOST)‐based neuromorphic motor control systems integrate sensing, processing, and actuation by mimicking biological synapses. With advantages such as low power consumption, tunable synaptic plasticity, and mechanical flexibility, they are emerging as next‐generation core technologies for real‐time ...
Sung‐Hwan Kim, Ju‐Hyeok Yun, Hea‐Lim Park, Sin‐Hyung Lee   +3 more
wiley   +1 more source

Negative Self-Perception and Self-Attitude of Sexuality Is a Risk Factor for Patient Dissatisfaction Following Penile Surgery with Small Intestinal Submucosa Grafting for the Treatment of Severe Peyronie's Disease. [PDF]

J Clin Med, 2019
Soave A, Laurich S, Dahlem R, Vetterlein MW, Engel O, Nieder T, Briken P, Rink M, Fisch M, Reiss P.   +9 more
europepmc   +1 more source

Relationship Between Knowledge and Compliance With Safety Measures: Evidence From COVID‐19

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT Compliance with health safety protocols is important for protecting public health, particularly in agricultural sectors where disease outbreaks can disrupt production and market access. Despite its economic significance, we know little about what drives protocol compliance.
Nilufer Cetik, Carola Grebitus, Lauren Chenarides   +2 more
wiley   +1 more source