Results 51 to 60 of about 346,363 (261)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Virtual reality and embodiment: rethinking self-construction and identity in therapeutic contexts

Frontiers in Virtual Reality
Immersive virtual reality has surfaced as a revolutionary instrument in psychology, clinical practice, and neuroscience creating unique opportunities to explore embodiment, identity, and therapeutic applications.
Vasudha Vasudha, Shalini Choudhary
doaj   +1 more source

Citations of \u27noster\u27 John Pecham in Richard Fleming\u27s Trinity Sunday sermon: evidence for the political use of liturgical music at the Council of Constance [PDF]

, 2008
This article examines a sermon for Trinity Sunday that was delivered by Richard Fleming at the Council of Constance in 1417. The author argues that Fleming’s citation of liturgical chant and a homily composed by John Pecham, together with certain ...
Nighman, Chris L.
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Family of Origin History, Psychological Distress, Quality of Childhood Memory, and Content of First and Recovered Childhood Memories [PDF]

, 1998
Objective: Individual differences in quality of childhood memory and recovered memories from childhood remain poorly understood. Therefore, this study tested several hypotheses which may help account for the large amount of variation that individuals ...
Melchert, Timothy P.
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

[Review of] David Delaney. Race, Place, & the Law [PDF]

, 1998
David Delaney\u27s work is informative and contributes to an understanding of race relations and the legal system. The central finding is that race relations exist in different spatial contexts at the same time.
Hood, David L.
core   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Processus de construction de soi et choix professionnel chez les étudiants camerounais

Éducation et Socialisation, 2015
In Cameroon, school guidance is the thing least shared within the educational community. Guidance counselor, true professional of school guidance, is made key and sometimes seen as a luxury, sometimes as sinecure.
François Xavier Kemtchuain Tague, Joseph Bomda   +1 more
doaj   +1 more source