Results 131 to 140 of about 4,502,505 (302)

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen   +7 more
wiley   +1 more source

Self-determination and decolonization

open access: yes, 2023
Self-determination and ...
Costas Laoutides (13065132)
core  

The mediating role of professional identity between role models and self-determination in medical students: A multicenter cross-sectional study.

open access: yesPLoS ONE
ObjectiveThis study aimed to investigate self-determination, explore the mediating role of professional identity between role models and self-determination, and detect how role models and professional identity contribute to the development of self ...
Jingjing Liu   +8 more
doaj   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao   +6 more
wiley   +1 more source

The Kremlin and the principle of self- determination

open access: yesCuadernos de Política Exterior Argentina
The paper attempts to analyze the principle of self-determination in the international agenda focusing on Moscow´s foreign policy since Gorbachev´s rejection of the Nagorno Karabagh Autonomous Region constitutional request to separate from the Soviet ...
Khatchik DerGhougassian, Ricardo Torres
doaj  

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang   +8 more
wiley   +1 more source

American Indian Self-Determination Through Self-Governance: The Only Policy That Has Ever Worked

open access: yes, 2022
In testimony before the Alyce Spotted Bear and Walter Soboleff Commission on Native Children on December 15, 2022, Joseph Kalt, Ford Foundation Professor of International Political Economy, Emeritus testified about the importance that American Indian ...
Kalt, Joseph
core  

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli   +5 more
wiley   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi   +8 more
wiley   +1 more source

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