Results 131 to 140 of about 2,062,495 (298)

The Necessary Architecture of Self-Regulating Teams [PDF]

open access: yes, 1997
In this paper we present the meaning of self-regulation in Self- Regulating Teams (SRTs) and show the importance of self- regulating teams in a learning organisation.
Johnson, Leslie, Stergiou, Maria
core   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Difficult circumstances: change the trajectory of self-development [PDF]

open access: yes, 2015
У статті виконаний аналіз постмодерної специфіки понять «особистість», «ідентичність», «саморозуміння». Відзначено, що у періоди кризової зміни життєвих обставин процеси самоідентифікування стають більш інтенсивними.
Березко, Іванна Василівна
core  

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

open access: yesAging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu   +8 more
wiley   +1 more source

The Influence of Supervision Development and Counselling Self-Efficacy towards Trainee Counsellor Performance [PDF]

open access: yes, 2007
The purpose of this study is to determine the influence of supervision development factors and counselling self-efficacy towards counsellor performance.
Wan Jaafar, Wan Marzuki
core  

The McCance Brain Care Score and Mortality: Evidence From a Large‐Scale Population‐Based Cohort

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives This study aimed to examine the relationship between the McCance Brain Care Score (BCS) and mortality in the general population. Methods We conducted a prospective, population‐based cohort study using data from the UK Biobank. Participants with complete data enabling calculation of BCS and full mortality information were included ...
Zhiqiang Xu, Xiaoxiao Wang, Nan Li
wiley   +1 more source

We Don't Need No Noumena? Freedom Through Rational Self-Cultivation in Kant [PDF]

open access: yes, 2016
In this paper I argue that we find in Kant a more plausible alternative to his transcendental conception of freedom. In the Metaphysics of Morals in particular, we find a naturalistic conception of freedom premised upon a ...
Chapman, Louise R.
core  

Prediction of Myasthenia Gravis Worsening: A Machine Learning Algorithm Using Wearables and Patient‐Reported Measures

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare disorder characterized by fluctuating muscle weakness with potential life‐threatening crises. Timely interventions may be delayed by limited access to care and fragmented documentation. Our objective was to develop predictive algorithms for MG deterioration using multimodal telemedicine data ...
Maike Stein   +7 more
wiley   +1 more source

The effect of trained principals on the professional (self) development of employees [PDF]

open access: yes, 2012
The matter election of principal in schools can sometimes become a political issue. All political parties are interested in this position, especially the ones that are now in power.
Agić, Hariz
core   +1 more source

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