Results 231 to 240 of about 5,817,872 (291)

Clinical Practice of the Proactive Health Concept in Chronic Disease Management: A Qualitative Study from the Perspective of Neurology Medical Staff. [PDF]

Risk Manag Healthc Policy
Xu X, Chen Y, Zhang Y, Lu L.
europepmc   +1 more source

Chemical Screening Identifies Danofloxacin as a Self‐Renewal Agonist of Embryonic Stem Cells through Alleviation of HDAC1‐Mediated Deacetylation of Tert and Prdm10

Advanced Science, EarlyView.
This study identified Danofloxacin as a novel supporter of the maintenance of mouse embryonic stem cell (ESC) pluripotency. It functions partially by inhibiting HDAC1, which increases specific histone acetylation marks and activates key genes like Tert and Prdm10.
Yan Zhang, Junxiang Ji, Baoxing Dong, Zhenhua Zhu, Xucheng Lv, Peng Chen, Wenqiang Liu, Min Zhou, Shou‐Dong Ye   +8 more
wiley   +1 more source

Research on Collaborative Management of Disinfection Supply Center and Operating Room Consumables Based on Information Ecology Theory. [PDF]

Med Devices (Auckl)
Su S, Yang J, Bai L, Xu Y.
europepmc   +1 more source

Deep Contrastive Learning for High‐Throughput Prediction of Drug Resistance Mutations from Sequences

Advanced Science, EarlyView.
This study presents DeepMutDTA, a deep learning framework aimed at predicting mutation‐induced changes in protein‐drug interactions and prioritizing variants potentially linked to drug resistance. Trained on large‐scale data, it incorporates SimSiam‐MuTF, a label‐aware contrastive fine‐tuning strategy that encourages separation between WT and MT ...
Xiaowen Hu, Pan Zhang, Shangqian Wu, Hao Sun, Minwei Li, Sophia Tsoka, Zizhang Sheng, Lei Deng   +7 more
wiley   +1 more source

Breast Cancer Patients' Parenting Concerns User Personas: A Qualitative Analysis. [PDF]

Curr Oncol
Zhang Y, Liu M, Fan X, Tu H, Wang Y, Hong J.   +5 more
europepmc   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

Dementia Diagnosis Underreporting and Care Engagement and Planning Among Older Adults.

JAMA Netw Open
Qian Y, Gavulic KA, Chen X.
europepmc   +1 more source

UK-Africa Leadership Fellowship for Antimicrobial Stewardship (UK-ALF-A): A Bilateral Learning Approach to Advancing AMS Expertise Among Pharmacists. [PDF]

Antibiotics (Basel)
Price S, Truong Y, Zadeh PS, Tumukunde G, Brandish C, Panford-Quainoo E, Cavanagh S, Obiri-Yeboah E, Nabiryo M, Ward E, Gülpinar G, Rutter V, Rosado H, Savieli C.   +13 more
europepmc   +1 more source

NeuroSuite for Long‐Term Functional and Structural Studies of Air‐Liquid Interface Cerebral Organoids

Advanced Science, EarlyView.
NeuroSuite provides a modular hardware‐software platform integrating Neuroweb and NeuroMaps to enable long‐term, in situ electrophysiological interrogation of air–liquid interface organoid slices while preserving tissue architecture. Its components can be used together or independently to capture real‐time activity, spatial network dynamics, and ...
Belquis Haider, Sagnik Middya, Daniel J. Lloyd‐Davies‐Sánchez, Nino F. Läubli, Sulay Vora, Jakob Träuble, Rohan N. Krajeski, Yuqing Feng, Daniel Duncko, Josiah S. Riley, Rubén Ruiz‐Mateos Serrano, Ole Paulsen, Madeline A. Lancaster, George G. Malliaras, Gabriele S. Kaminski Schierle   +14 more
wiley   +1 more source

A multi-faceted approach to the study of the relationship between self-esteem and the self-prioritization effect. [PDF]

Psychol Res
Atzeni L, Castelli L, Dalmaso M, Galfano G, Penolazzi B.   +4 more
europepmc   +1 more source