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Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
IMPACT OF SELF ESTEEM & SUPPORT ON STUDENT PERFORMANCE [PDF]
Education is life blood for development of country. This paper explores the impact of various factors on student performance. Data was collected from ten (10) Govt. & Private schools in Rawalpindi.
Akmal SHAHZAD +3 more
doaj
Youth Empowerment Programs for Improving Self‐Efficacy and Self‐Esteem of Adolescents
Do youth empowerment programs improve adolescents' self‐esteem and self‐efficacy? A Campbell systematic review of international research suggests that there is not enough reliable evidence to substantiate the popular expectation that these programs are ...
Matthew Morton, Paul Montgomery
doaj +1 more source
Hopelessly Mortal: The Role of Mortality Salience, Immortality and Trait Self-esteem in Personal Hope [PDF]
Do people lose hope when thinking about death? Based on Terror Management Theory, we predicted that thoughts of death (i.e., mortality salience) would reduce personal hope for people low, but not high, in self-esteem, and that this reduction in hope ...
Heflick, Nathan A, Wisman, Arnaud
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Self and Body Esteem Perception in Multiple Sclerosis
Self esteem and body esteem were examined in a group of 35 relapsing-remitting multiple sclerosis (MS) patients using the Body Esteem Scale (BES) and the Eysenck Self Esteem Scale (ESES) and compared to age and sex matched normal controls.
Yoram Barak +3 more
doaj +1 more source
Church attendance and self-esteem among adolescents [PDF]
A total of 279 young people (123 males and 156 females) aged between 12 and 16 years of age attending one school in Wales completed the Coopersmith Self-Esteem Inventory alongside a measure of frequency of church attendance.
Robbins, Mandy +2 more
core
Why human connection is the true metric of research success
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
Self-esteem has been traditionally assessed via self-report (explicit self-esteem: ESE). However, the limitations of self-report have prompted efforts to assess self-esteem indirectly (implicit self-esteem: ISE).
Astrid Schütz +9 more
core +1 more source

