Results 41 to 50 of about 77,350 (261)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Frontiers in Political ScienceA key driver in the digital transformation of commercial, educational, organizational and social systems is the increasing footprint of Artificial Intelligence (AI).
Jeremy Pitt +2 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
A Person for Local Self-Government or Local Self-Government for a Person
Administrative Consulting, 2021 .
openaire +3 more sources
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
THE COMMUNITY-BASED TOURISM. A FOCUS FROM THE COMMONS AND THE SOCIO-ECOLOGICAL SYSTEM APPROACH
Ra Ximhai, 2018 This paper aims to propose a methodological approach based on the theory of the commons and the complex socio-ecological systems, which is allowing the analysis of community-based tourism using their natural resources collectively.
Alma Rafaela Bojórquez-Vargas +3 more
doaj
Local self government and formation of self governing in rural areas
Management Theory and Studies for Rural Business and Infrastructure Development, 2014 Nowadays, in public administration observed high dichotomy between legal regulation of selfgovernment (de jure) and local self-government practice (de facto) – self management. This makes communication, harmony and compatibility problem between local self-organization and organization of self-management in rural areas.
Vytautas Pilipavičius +1 more
openaire +2 more sources
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Socialiniai Tyrimai, 2019 The state governance model is established by Constitution. In the Constitution of the Republic of Lithuania, there is a separate section dedicated to local self-governance and its management, that shows not only the state’s recognition of local self ...
Karolis Kaklys
doaj +1 more source