Results 71 to 80 of about 197,167 (266)

Self‐Healing Hydrogels: Mechanisms and Biomedical Applications

MedComm
Hydrogels have emerged as dependable candidates for tissue repair because of their exceptional biocompatibility and tunable mechanical properties. However, conventional hydrogels are vulnerable to damage owing to mechanical stress and environmental ...
Lingling Xue, Ran An, Junqi Zhao, Mengdi Qiu, Zhongxia Wang, Haozhen Ren, Decai Yu, Xinhua Zhu   +7 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Toughening Self‐Healing Elastomers with Chain Mobility

Advanced Science
Enhancing fracture toughness and self‐healing within soft elastomers is crucial to prolonging the operational lifetimes of soft devices. Herein, it is revealed that tuning the polymer chain mobilities of carboxylated‐functionalized polyurethane through ...
Matthew Wei Ming Tan, Patrick Michael Thornton, Gurunathan Thangavel, Hyunwoo Bark, Reinhold Dauskardt, Pooi See Lee   +5 more
doaj   +1 more source

Recent Advances of Self-Healing Materials for Civil Engineering: Models and Simulations

Buildings
Empowering materials with self-healing capabilities is an attractive approach for sustainable development. This strategy involves using different methods to automatically heal microcracks and damages that occur during the service life of materials or ...
Cen-Ying Liao, Lin Zhang, Si-Yu Hu, Shuai-Jie Xia, D. M. Li   +4 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Humidity‐Induced Self‐Oscillating and Self‐Healing Hypercrosslinked Metal–Organic Polyhedra Membranes

Advanced Science
Designing autonomously oscillating materials is highly desirable for emerging smart material fields but challenging. Herein, a type of hypercrosslinked metal–organic polyhedra (HCMOPs) membranes formed by covalent crosslinking of boronic acid‐modified Zr‐
Jiamin Li, Zhaoyi Liu, Jinjin Liu, Xue Liu, Yang Luo, Jiajie Liang, Zhenjie Zhang   +6 more
doaj   +1 more source

The Influence of Calcium-Based Whisker Self-Healing Agent on Self-Healing of Oil Well Set Cement Cracks in CCUS Wells

Zuanjingye yu wanjingye
In wells for carbon capture, utilization and storage (CCUS), cement sheaths are easy to get chemically damaged, hence reducing their service life. A study was conducted to enhance the self-healing capacity of cement sheaths by reacting calcium-based ...
Hongchang CAO, Donghong DANG, Ye ZHANG, Qiang REN, Jingli LIU, Yan LIU, Song PENG, Jun MA   +7 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Self‐Healing Microsupercapacitors with Size‐Dependent 2D MXene

ChemElectroChem, 2020
Very recently, 2D MXene has attracted a lot of attention in energy storage, due to its large specific surface area, good hydrophilicity, good conductivity and adjustable composition.
Xingxing Li, Yanan Ma, Peizhi Shen, Chuankun Zhang, Jinfeng Yan, Yingbo Xia, Prof. Shijun Luo, Prof. Yihua Gao   +7 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source