Results 51 to 60 of about 195,040 (267)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Self‐Healing Ionogel‐Enabled Self‐Healing and Wide‐Temperature Flexible Zinc‐Air Batteries with Ultra‐Long Cycling Lives

Advanced Science
Hydrogel‐based zinc‐air batteries (ZABs) are promising flexible rechargeable batteries. However, the practical application of hydrogel‐based ZABs is limited by their short service life, narrow operating temperature range, and repair difficulty. Herein, a
Hongli Li, Fuchang Xu, Yang Li, Junqi Sun   +3 more
doaj   +1 more source

Fast self-healing gradients [PDF]

Proceedings of the 2008 ACM symposium on Applied computing, 2008
We present CRF-Gradient, a self-healing gradient algorithm that provably reconfigures in O(diameter) time. Self-healing gradients are a frequently used building block for distributed self-healing systems, but previous algorithms either have a healing rate limited by the shortest link in the network or must rebuild invalid regions from scratch.
Jacob Beal, Jonathan Bachrach, Daniel Vickery, Mark M. Tobenkin   +3 more
openaire   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Mechanically Robust, Recyclable, and Self‐Healing Polyimine Networks

Advanced Science, 2023
To achieve energy saving and emission reduction goals, recyclable and healable thermoset materials are highly attractive. Polymer copolymerization has been proven to be a critical strategy for preparing high‐performance polymeric materials.
Ping Yu, Haiyue Wang, Ting Li, Guimei Wang, Zichen Jia, Xinyu Dong, Yang Xu, Qilin Ma, Dongen Zhang, Hongliang Ding, Bin Yu   +10 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Self‐healing Coatings Based on Epoxy Vitrimers

Macromolecular Materials and Engineering
The present study focuses on the development of epoxy‐based vitrimeric coatings with thermal‐healing ability. For this purpose, ethylene glycol diglycidyl ether (EG) is crosslinked with methyl nadic anhydride (MNA) in the presence of 1‐methylimidazole (1‐
Angela Marotta, Fabio Scherillo, Giovanni Filippone, Martina Salzano de Luna, Veronica Ambrogi   +4 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Self‐Healing Hydrogels: Mechanisms and Biomedical Applications

MedComm
Hydrogels have emerged as dependable candidates for tissue repair because of their exceptional biocompatibility and tunable mechanical properties. However, conventional hydrogels are vulnerable to damage owing to mechanical stress and environmental ...
Lingling Xue, Ran An, Junqi Zhao, Mengdi Qiu, Zhongxia Wang, Haozhen Ren, Decai Yu, Xinhua Zhu   +7 more
doaj   +1 more source