Results 121 to 130 of about 5,645,164 (308)

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Progress in the development of self-healing polyurethane materials

Resources Chemicals and Materials
As a significant branch of smart materials, self-healing polyurethane materials mimic the biological damage repair mechanisms and have been widely applied in flexible electronics, functional coatings, biomedicine, and other fields.
Yongyin Zhu, Henghui Deng, Huizhou Luo, Ying Luo, Yu Chen, Zehong Chen, Chaoqun Zhang   +6 more
doaj   +1 more source

Self-healing of polymer modified concrete

Alexandria Engineering Journal, 2011
Self healing phenomenon of concrete has been observed in traditional, fibrous, self compacting concrete. This phenomenon occurred mainly due to the presence of unhydrated cement particles in the presence of water. Mechanism of polymer in concrete depends
Abd_Elmoaty M. Abd_Elmoaty
doaj   +1 more source

Self‐Healing Molecular Crystals

Angewandte Chemie, 2016
AbstractOne of the most inevitable limitations of any material that is exposed to mechanical impact is that they are inexorably prone to mechanical damage, such as cracking, denting, gouging, or wearing. To confront this challenge, the field of polymers has developed materials that are capable of autonomous self‐healing and recover their macroscopic ...
Patrick Commins, Hideyuki Hara, Panče Naumov   +2 more
openaire   +2 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Self-healing Properties of Engineered Cementitious Composites (ECC)

, 2020
Concrete is the most widely used construction material globally; however, its brittle behavior makes it prone to cracking, negatively impacting the structural durability and sustainability of concrete infrastructure.
Mahmoodi, Sina
core  

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Investigation on Regularities of Self‐Healing Breakdown in Metallized Film Capacitors for AC Application

Advanced Materials Interfaces
Metallized film capacitors (MFCs) exhibit a distinctive self‐healing capability, making them particularly suitable for reactive compensation in high‐voltage power systems. However, frequent self‐healing breakdowns or failures can significantly compromise
Fei Yan, Jiao Zhou, Xiang Huang, Huiwen He, Qiaogen Zhang   +4 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source