Results 61 to 70 of about 9,220,977 (235)

Terapeutiska utflykter

Kulturella Perspektiv, 2010
Narratives about Europeans entering so called pre-modern cultures have a long tradition, and "tribe-tv" based on arranged visits from Europeans to "the world's remotest tribes" has become a growing genre today.
Linda Berg
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

A State of the Art of Self Help Groups in India [PDF]

, 2011
This paper considers the strategies of self help group for micro-enterprise development in rural areas. It seeks to answer the question of whether and under which conditions self help groups are an effective vehicle for organizing and representing local ...
Singh, S., Ruivenkamp, G.T.P., Jongerden, J.P.   +2 more
core  

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Working together for self help

, 1989
Final report of the Self Help AllianceSIGLEAvailable from British Library Document Supply Centre- DSC:q90/06294(Working) / BLDSC - British Library Document Supply CentreGBUnited ...
Bradburn, J. (comp.), Self Help Alliance (United Kingdom)   +1 more
core  

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

GUIDED SELF-HELP IN THE TREATMENT OF COMMON MENTAL HEALTH DISORDERS – THE DEVELOPMENT OF THE FINNISH GUIDED SELF-HELP (F-GSH) MODEL [PDF]

Psychiatria Fennica
Increasing access to short-term, evidence-based psychological therapies in primary care or community-based settings is a key strategy for responding to the rapid increase of demand for mental health services seen in most Western countries.
KASPERI MIKKONEN, ALESSANDRA BOMBINO, ALEX VILLA, SARA NURMINEN, REETTA-MARIA ROIHA, PASI ROSLUND, JAN-HENRY STENBERG, JESPER EKELUND, SUOMA E. SAARNI, SAMULI SAARNI
doaj  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source