Results 31 to 40 of about 1,220,410 (294)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Choosing the Appropriate Assistive Device: A Card-Sorting Activity

MedEdPORTAL, 2008
Introduction This resource is a 30-40 minute instructional activity designed for small groups of six to eight medical trainees to apply basic information learned about assistive devices.
Maria van Zuilen, Osvaldo Rodriguez, Miguel Paniagua, Michael Mintzer   +3 more
doaj   +1 more source

Leveraging advances in diabetes technologies in primary care: a narrative review

Annals of Medicine, 2021
Primary care providers (PCPs) play an important role in providing medical care for patients with type 2 diabetes. Advancements in diabetes technologies can assist PCPs in providing personalised care that addresses each patient’s individual needs ...
Bruce Bode, Aaron King, David Russell-Jones, Liana K. Billings   +3 more
doaj   +1 more source

Prediction of Myasthenia Gravis Worsening: A Machine Learning Algorithm Using Wearables and Patient‐Reported Measures

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare disorder characterized by fluctuating muscle weakness with potential life‐threatening crises. Timely interventions may be delayed by limited access to care and fragmented documentation. Our objective was to develop predictive algorithms for MG deterioration using multimodal telemedicine data ...
Maike Stein, Haoqi Sun, Sophie Lehnerer, Lea Gerischer, Maximilian Mönch, Christian Meisel, Andreas Meisel, Pushpa Narayanaswami   +7 more
wiley   +1 more source

Lack of time and dependence on significant others: Occupational therapists´ experiences of prescribing time assistive technology for persons with dementia

Scandinavian Journal of Occupational Therapy, 2020
Background: There is lack of knowledge on how occupational therapists (OTs) assess daily time management (DTM) for persons with dementia (PwDs) and on which aspects affect prescription of time assistive technology (AT).
Ann-Christine Persson, Inga-Lill Boman, Lena Dahlberg, Gunnel Janeslätt, Marika C. Möller, Monika Löfgren   +5 more
doaj   +1 more source

Investigating the Privacy and Security of the SimpliSafe Security System on Android and iOS

Journal of Cybersecurity and Privacy, 2023
The emergence of the Internet of Things technologies and the increase and convenience of smart home devices have contributed to the growth of self-installed home security systems. While home security devices have become more accessible and can help users
Shinelle Hutchinson, Miloš Stanković, Samuel Ho, Shiva Houshmand, Umit Karabiyik   +4 more
doaj   +1 more source

Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein, Maximilian Mönch, Meret Herdick, Frauke Stascheit, Sarah Hoffmann, Hannah Preßler, Philipp Mergenthaler, Carla Dusemund, Paolo Doksani, Haoqi Sun, Pushpa Narayanaswami, Andreas Meisel, Lea Gerischer, Sophie Lehnerer   +13 more
wiley   +1 more source

A semi-automatic design method of handwriting self-help devices for individuals with upper limb dysfunctions

Journal of Biomechanical Science and Engineering
The global demand for assistive devices to support individuals with disabilities is increasing, yet their accessibility remains limited. Self-help devices (SHDs), particularly for handwriting tasks, play a pivotal role in enhancing independence.
Qian LI, Jun SUZURIKAWA, Tamano TANAKA, Makoto YOSHIDA, Kazunori HASE   +4 more
doaj   +1 more source

Prototyping a Capacitive Sensing Device for Gesture Recognition [PDF]

, 2019
Capacitive sensing is a technology that can detect proximity and touch. It can also be utilized to measure position and acceleration of gesture motions.
Lin, Chenglong
core   +2 more sources

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick, Nomin Enkhtsetseg, Joseph Sadok, Matheus Mochetti, Annabel Sorby Adams, Jennifer Guo, Cristina Trapaga Hacker, Isabella Gomez Hjerthen, Seungwon Lee, Siddharth Satish, Andrew S. Ham, Justin Hill, Denis Balaban, Kevin Kyle, Rebecca L. Gillani, Marcelo Matiello, Aleksandar Videnovic, Eric C. Klawiter, W. Taylor Kimberly, Farrah J. Mateen   +19 more
wiley   +1 more source