Results 101 to 110 of about 6,295,463 (258)
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
, 2017 The foreword to the book, The Self as Subject: Autoethnographic Research into Identity, Culture, and Academic Librarianship. Using autoethnography as their research method, 21 academic librarian authors investigate aspects of what it means to be a ...
Fister, Barbara;
core
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
“The Maze Factor” Vs. “The Solar Eye”: Identities of Walkers and Watchers [PDF]
University of Bucharest Review. Literary and Cultural Studies Series, 2016 This paper will aim to investigate Joyce’s Ulysses, the paradigmatic urban novel, in juxtaposition with Huxley’s dystopian Brave New World and Alasdair Gray’s ambiguous Lanark on the theoretical basis of modern urban planning, environmental psychology,
Marija Spirkovska
doaj
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
Agnes Grey’s Search for Self-Identity in Agnes Grey by Anne Bronte
Acuity, 2019 This study aims to reveal, identify and describe Agnes Grey's search for self-identity. Also, the writer of the thesis wants to show that the situations in Agnes Grey's adolescence period are the same as the real life of the author, Anne Bronte.
Yanti Rahayuningsih
doaj
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Constructing Armân/Vlach Ethnic Identity [PDF]
HyperCultura, 2014 Constructing identity (ethnicity, in this case) is subject to the action of several elements shaping the complex relationships between the individual and the communities of which he/she is a member, with direct and indirect effects: the SELF (beliefs ...
Mariana Bara
doaj