Results 71 to 80 of about 11,861,823 (318)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A Life of the ‘Other’ and a Story of the ‘Self’: Shivarani Devi in "Premcand ghar me͂"

Cracow Indological Studies, 2018
A Life of the ‘Other’ and a Story of the ‘Self’: Shivarani Devi in "Premcand ghar me͂" This paper will deal with Shivarani Devi’s (1890–1976) Premcand ghar mẽ, a literary memoir-cum-biography of her husband Premchand, a pioneer of Hindi literature ...
Alaka Atreya Chudal
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Four aspects of self-image close to death at home

International Journal of Qualitative Studies on Health & Well-Being, 2011
Living close to death means an inevitable confrontation with one's own existential limitation. In this article, we argue that everyday life close to death embodies an identity work in progress.
Ida Carlander, Britt-Marie Ternestedt, Eva Sahlberg-Blom, Ingrid Hellström, Jonas Sandberg   +4 more
doaj   +1 more source

Body image and self-concept in adolescent girls

, 2006
Anorexia Nervosa has been recently recognized as one of the most common chronic illnesses that affects the female adolescent population today. Although there has been an abundance of research into eating disorders in a variety of fields, significant ...
Halse, Christine, Ha, My Trinh, Marsh, Herbert W., Martin, Andrew J.   +3 more
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Repercussões do acometimento cutâneo na vida das pessoas: sociopoetizando a autoimagem e a autoestima [Repercussions of skin conditions in people’s lives: socio-poetizing self-image and self-esteem]

Revista Enfermagem UERJ, 2014
Teve-se como objetivo identificar influências do acometimento cutâneo na autoimagem e autoestima das pessoas. Método sociopoético, utilizando o dispositivo analítico Grupo-Pesquisador, formado por 18 clientes com afecções dermatológicas.
Iraci dos Santos, Patrícia Britto Ribeiro de Jesus, Euzeli da Silva Brandão, Elias Barbosa Oliveira, Alexandre Vicente da Silva   +4 more
doaj  

Unveiling the mediating role of teachers’ self-image in the link between collective efficacy and professional commitment

International Journal of Adolescence and Youth
This study explores the relationships among collective teacher efficacy (CTE), teachers’ self-image, and teacher commitment in Ethiopia, using structural equation modeling with 342 primary and middle school teachers.
Sintayehu Belay, Tadesse Melesse
doaj   +1 more source

Testing for longitudinal bidirectional associations between self-compassion, self-criticism, and positive body image components

Previous cross-sectional studies have reported associations between self-compassion, self-criticism, and positive body image, yet prospective studies establishing the temporal order of these relationships are missing.
Anderson, C, Moffitt, R, Tylka, TL, Linardon, J   +3 more
core   +1 more source

Feeling like me again : a grounded theory of the role of breast reconstruction surgery in self-image

, 2013
The present study aimed to develop a theoretical understanding of the role of breast reconstruction in women's self-image. Semi-structured interviews were conducted with 10 women from breast cancer support groups who had undergone breast reconstruction ...
Mckean, Lindsay N., Mackean, L, Newman, Emily; id_orcid, McKean, Lindsay, Newman, E, Adair, Pauline, Newman, Emily F., Adair, Pauline; id_orcid   +7 more
core   +1 more source