Results 41 to 50 of about 7,849,891 (287)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Self-injurious behavior in anorexia nervosa.
, 2000 Recent reports have postulated the existence of two different types of self-injurious behavior: impulsive and compulsive. The aim of the present study is to analyze the dimensionality of self-injurious behavior and to study the link between self ...
SANTONASTASO, PAOLO, FAVARO, ANGELA
core +1 more source
Etiology and risk factors for non-suicidal self-injurious behavior
Медицинский вестник Юга России, 2023 The article presents a review of the literature on the subject of non-suicidal self-injurious behavior (NSSI), the study of which attracts the attention of authors, both in the Russian Federation and around the world. Large meta-analyses of NSSP studies,
E. V. Darin, O. G. Zaitseva
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Gender differences and deliberate self-injury
, 2014 Self-injurious behaviours are associated with long-term negative consequences for social, emotional and physical wellbeing. As such, and in order to inform the development of both treatment plans and preventive approaches, it is necessary to develop a ...
de Haast, Chloe
core +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Self-injurious behavior of children with autism in Vietnam: A cross sectional study [PDF]
, 2022 This study explored self-injurious behavior (SIB) of autistic children in Vietnam through a cross-sectional design. 60 informants, including 57 parents and 3 caregivers completed the questionnaire on problem behavior consisting of aggression, self-injury,
Pham, Thi Thuy Hang +11 more
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Psychological aspects of body perception in depression with non-suicidal self-injury
European Psychiatry, 2022 Introduction Emotional regulation appears to be a key factor in self-injury. But body image also may play an important role in self-harming. Objectives Analysis of the relationship between non-suicidal self-injurious behavior and various aspects of ...
S. Enikolopov +4 more
doaj +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source